Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.

<h4>Objective</h4>An insertion/deletion (I/D) variant in the angiotensin-converting enzyme (ACE) gene was associated with ACE inhibitor (ACEI)-related cough in previous studies. However, the results were inconsistent. Our objective was to assess the relationship between the ACE I/D polym...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ya-Feng Li, Xiao-Ming Zhu, Fan Liu, Chuan-Shi Xiao, Yun-Fei Bian, Hong Li, Jun Cai, Rong-Shan Li, Xin-Chun Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73c3bae0b0a547f3a49953f10ac8e2c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:73c3bae0b0a547f3a49953f10ac8e2c0
record_format	dspace
spelling	oai:doaj.org-article:73c3bae0b0a547f3a49953f10ac8e2c02021-11-18T07:15:04ZAngiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.1932-620310.1371/journal.pone.0037396https://doaj.org/article/73c3bae0b0a547f3a49953f10ac8e2c02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723835/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>An insertion/deletion (I/D) variant in the angiotensin-converting enzyme (ACE) gene was associated with ACE inhibitor (ACEI)-related cough in previous studies. However, the results were inconsistent. Our objective was to assess the relationship between the ACE I/D polymorphism and ACEI-related cough by meta-analysis and to summarize all studies that are related to ACE I/D polymorphism and ACEI-cough and make a summary conclusion to provide reference for the researchers who attempt to conduct such a study.<h4>Methods</h4>Databases including PubMed, EMbase, Cochrane Library, and China National Knowledge Infrastructure, were searched for genetic association studies. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Metaregression and subgroup analyses were performed to identify the source of heterogeneity.<h4>Results</h4>Eleven trials, including 906 cases (ACEI-related cough) and 1,175 controls, were reviewed in the present meta-analysis. The random effects pooled OR was 1.16 (95%CI: 0.78-1.74, p=0.46) in the dominant model and 1.61 (95%CI: 1.18-2.20, p=0.003) in the recessive model. Heterogeneity was found among and within studies. Metaregression indicated that the effect size was positively associated with age and negatively associated with follow-up duration of ACEI treatment. Subgroup analysis revealed a significant association between ACE I/D polymorphism and ACEI-related cough in studies with mean age >60 y, but not in studies with mean age ≤ 60 y. No heterogeneity was found within each mean age subgroup. We also found no association between ACE I/D polymorphism and ACEI-related cough in studies with follow-up>2 mo or in studies in Caucasians. No heterogeneity was detected in these two subgroups.<h4>Conclusions</h4>Synthesis of the available evidence supports ACE I/D polymorphism as an age-dependent predictor for risk of ACEI-related cough.Ya-Feng LiXiao-Ming ZhuFan LiuChuan-Shi XiaoYun-Fei BianHong LiJun CaiRong-Shan LiXin-Chun YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e37396 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ya-Feng Li Xiao-Ming Zhu Fan Liu Chuan-Shi Xiao Yun-Fei Bian Hong Li Jun Cai Rong-Shan Li Xin-Chun Yang Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
description	<h4>Objective</h4>An insertion/deletion (I/D) variant in the angiotensin-converting enzyme (ACE) gene was associated with ACE inhibitor (ACEI)-related cough in previous studies. However, the results were inconsistent. Our objective was to assess the relationship between the ACE I/D polymorphism and ACEI-related cough by meta-analysis and to summarize all studies that are related to ACE I/D polymorphism and ACEI-cough and make a summary conclusion to provide reference for the researchers who attempt to conduct such a study.<h4>Methods</h4>Databases including PubMed, EMbase, Cochrane Library, and China National Knowledge Infrastructure, were searched for genetic association studies. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Metaregression and subgroup analyses were performed to identify the source of heterogeneity.<h4>Results</h4>Eleven trials, including 906 cases (ACEI-related cough) and 1,175 controls, were reviewed in the present meta-analysis. The random effects pooled OR was 1.16 (95%CI: 0.78-1.74, p=0.46) in the dominant model and 1.61 (95%CI: 1.18-2.20, p=0.003) in the recessive model. Heterogeneity was found among and within studies. Metaregression indicated that the effect size was positively associated with age and negatively associated with follow-up duration of ACEI treatment. Subgroup analysis revealed a significant association between ACE I/D polymorphism and ACEI-related cough in studies with mean age >60 y, but not in studies with mean age ≤ 60 y. No heterogeneity was found within each mean age subgroup. We also found no association between ACE I/D polymorphism and ACEI-related cough in studies with follow-up>2 mo or in studies in Caucasians. No heterogeneity was detected in these two subgroups.<h4>Conclusions</h4>Synthesis of the available evidence supports ACE I/D polymorphism as an age-dependent predictor for risk of ACEI-related cough.
format	article
author	Ya-Feng Li Xiao-Ming Zhu Fan Liu Chuan-Shi Xiao Yun-Fei Bian Hong Li Jun Cai Rong-Shan Li Xin-Chun Yang
author_facet	Ya-Feng Li Xiao-Ming Zhu Fan Liu Chuan-Shi Xiao Yun-Fei Bian Hong Li Jun Cai Rong-Shan Li Xin-Chun Yang
author_sort	Ya-Feng Li
title	Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
title_short	Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
title_full	Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
title_fullStr	Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
title_full_unstemmed	Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
title_sort	angiotensin-converting enzyme (ace) gene insertion/deletion polymorphism and ace inhibitor-related cough: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/73c3bae0b0a547f3a49953f10ac8e2c0
work_keys_str_mv	AT yafengli angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT xiaomingzhu angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT fanliu angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT chuanshixiao angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT yunfeibian angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT hongli angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT juncai angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT rongshanli angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis AT xinchunyang angiotensinconvertingenzymeacegeneinsertiondeletionpolymorphismandaceinhibitorrelatedcoughametaanalysis
_version_	1718423733266284544

Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.

Ejemplares similares