NMDA receptor-dependent plasticity in the nucleus accumbens connects reward-predictive cues to approach responses

Conditioned stimuli elicit phasic changes in nucleus accumbens (NAc) firing that invigorate approach responses to predicted rewards. Here the authors show that NAc neurons acquire cue-evoked responses during learning as a result of excitatory plasticity within the NAc.

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Detalles Bibliográficos
Autores principales: Mercedes Vega-Villar, Jon C. Horvitz, Saleem M. Nicola
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/73c68206a0934f93bb5073cf24fe66a9
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Descripción
Sumario:Conditioned stimuli elicit phasic changes in nucleus accumbens (NAc) firing that invigorate approach responses to predicted rewards. Here the authors show that NAc neurons acquire cue-evoked responses during learning as a result of excitatory plasticity within the NAc.