T cell costimulation blockade blunts pressure overload-induced heart failure

Abatacept is an FDA-approved drug used for treatment of rheumatoid arthritis. Here the authors show that abatacept reduces cardiomyocyte death in a mouse model of heart failure by inhibiting activation and heart infiltration of T cells and macrophages, an effect mediated by IL-10, suggesting a poten...

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Autores principales:	Marinos Kallikourdis, Elisa Martini, Pierluigi Carullo, Claudia Sardi, Giuliana Roselli, Carolina M. Greco, Debora Vignali, Federica Riva, Anne Marie Ormbostad Berre, Tomas O. Stølen, Andrea Fumero, Giuseppe Faggian, Elisa Di Pasquale, Leonardo Elia, Cristiano Rumio, Daniele Catalucci, Roberto Papait, Gianluigi Condorelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73c739f75c0e45a385907278d0b7888b
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spelling	oai:doaj.org-article:73c739f75c0e45a385907278d0b7888b2021-12-02T15:38:58ZT cell costimulation blockade blunts pressure overload-induced heart failure10.1038/ncomms146802041-1723https://doaj.org/article/73c739f75c0e45a385907278d0b7888b2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14680https://doaj.org/toc/2041-1723Abatacept is an FDA-approved drug used for treatment of rheumatoid arthritis. Here the authors show that abatacept reduces cardiomyocyte death in a mouse model of heart failure by inhibiting activation and heart infiltration of T cells and macrophages, an effect mediated by IL-10, suggesting a potential therapy for heart failure.Marinos KallikourdisElisa MartiniPierluigi CarulloClaudia SardiGiuliana RoselliCarolina M. GrecoDebora VignaliFederica RivaAnne Marie Ormbostad BerreTomas O. StølenAndrea FumeroGiuseppe FaggianElisa Di PasqualeLeonardo EliaCristiano RumioDaniele CatalucciRoberto PapaitGianluigi CondorelliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marinos Kallikourdis Elisa Martini Pierluigi Carullo Claudia Sardi Giuliana Roselli Carolina M. Greco Debora Vignali Federica Riva Anne Marie Ormbostad Berre Tomas O. Stølen Andrea Fumero Giuseppe Faggian Elisa Di Pasquale Leonardo Elia Cristiano Rumio Daniele Catalucci Roberto Papait Gianluigi Condorelli T cell costimulation blockade blunts pressure overload-induced heart failure
description	Abatacept is an FDA-approved drug used for treatment of rheumatoid arthritis. Here the authors show that abatacept reduces cardiomyocyte death in a mouse model of heart failure by inhibiting activation and heart infiltration of T cells and macrophages, an effect mediated by IL-10, suggesting a potential therapy for heart failure.
format	article
author	Marinos Kallikourdis Elisa Martini Pierluigi Carullo Claudia Sardi Giuliana Roselli Carolina M. Greco Debora Vignali Federica Riva Anne Marie Ormbostad Berre Tomas O. Stølen Andrea Fumero Giuseppe Faggian Elisa Di Pasquale Leonardo Elia Cristiano Rumio Daniele Catalucci Roberto Papait Gianluigi Condorelli
author_facet	Marinos Kallikourdis Elisa Martini Pierluigi Carullo Claudia Sardi Giuliana Roselli Carolina M. Greco Debora Vignali Federica Riva Anne Marie Ormbostad Berre Tomas O. Stølen Andrea Fumero Giuseppe Faggian Elisa Di Pasquale Leonardo Elia Cristiano Rumio Daniele Catalucci Roberto Papait Gianluigi Condorelli
author_sort	Marinos Kallikourdis
title	T cell costimulation blockade blunts pressure overload-induced heart failure
title_short	T cell costimulation blockade blunts pressure overload-induced heart failure
title_full	T cell costimulation blockade blunts pressure overload-induced heart failure
title_fullStr	T cell costimulation blockade blunts pressure overload-induced heart failure
title_full_unstemmed	T cell costimulation blockade blunts pressure overload-induced heart failure
title_sort	t cell costimulation blockade blunts pressure overload-induced heart failure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/73c739f75c0e45a385907278d0b7888b
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T cell costimulation blockade blunts pressure overload-induced heart failure

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