FGF2 cooperates with IL-17 to promote autoimmune inflammation

Abstract IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis. Here, we report a pathogenic role of the FGF2-IL-17 cooperation i...

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Autores principales:	Xinrui Shao, Siyuan Chen, Daping Yang, Mengtao Cao, Yikun Yao, Zhengxi Wu, Ningli Li, Nan Shen, Xiaoxia Li, Xinyang Song, Youcun Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73c7aea82a264b86b2b5961d19bf7011
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spelling	oai:doaj.org-article:73c7aea82a264b86b2b5961d19bf70112021-12-02T16:06:09ZFGF2 cooperates with IL-17 to promote autoimmune inflammation10.1038/s41598-017-07597-82045-2322https://doaj.org/article/73c7aea82a264b86b2b5961d19bf70112017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07597-8https://doaj.org/toc/2045-2322Abstract IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis. Here, we report a pathogenic role of the FGF2-IL-17 cooperation in the pathogenesis of autoimmune arthritis. Combined treatment with FGF2 and IL-17 synergistically induced ERK activation as well as the production of cytokines and chemokines in human synovial intimal resident fibroblast-like synoviocytes (FLS). Furthermore, ectopic expression of FGF2 in mouse joints potentiated IL-17-induced inflammatory cytokine and chemokine production in the tissue. In the collagen-induced arthritis (CIA) model, while ectopic expression of FGF2 in vivo exacerbated tissue inflammation and disease symptom in the wild-type controls, the effect was largely blunted in Il17a −/− mice. Taken together, our study suggests that FGF2 cooperates with IL-17 to promote the pathogenesis of autoimmune arthritis by cooperating with IL-17 to induce inflammatory response.Xinrui ShaoSiyuan ChenDaping YangMengtao CaoYikun YaoZhengxi WuNingli LiNan ShenXiaoxia LiXinyang SongYoucun QianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xinrui Shao Siyuan Chen Daping Yang Mengtao Cao Yikun Yao Zhengxi Wu Ningli Li Nan Shen Xiaoxia Li Xinyang Song Youcun Qian FGF2 cooperates with IL-17 to promote autoimmune inflammation
description	Abstract IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis. Here, we report a pathogenic role of the FGF2-IL-17 cooperation in the pathogenesis of autoimmune arthritis. Combined treatment with FGF2 and IL-17 synergistically induced ERK activation as well as the production of cytokines and chemokines in human synovial intimal resident fibroblast-like synoviocytes (FLS). Furthermore, ectopic expression of FGF2 in mouse joints potentiated IL-17-induced inflammatory cytokine and chemokine production in the tissue. In the collagen-induced arthritis (CIA) model, while ectopic expression of FGF2 in vivo exacerbated tissue inflammation and disease symptom in the wild-type controls, the effect was largely blunted in Il17a −/− mice. Taken together, our study suggests that FGF2 cooperates with IL-17 to promote the pathogenesis of autoimmune arthritis by cooperating with IL-17 to induce inflammatory response.
format	article
author	Xinrui Shao Siyuan Chen Daping Yang Mengtao Cao Yikun Yao Zhengxi Wu Ningli Li Nan Shen Xiaoxia Li Xinyang Song Youcun Qian
author_facet	Xinrui Shao Siyuan Chen Daping Yang Mengtao Cao Yikun Yao Zhengxi Wu Ningli Li Nan Shen Xiaoxia Li Xinyang Song Youcun Qian
author_sort	Xinrui Shao
title	FGF2 cooperates with IL-17 to promote autoimmune inflammation
title_short	FGF2 cooperates with IL-17 to promote autoimmune inflammation
title_full	FGF2 cooperates with IL-17 to promote autoimmune inflammation
title_fullStr	FGF2 cooperates with IL-17 to promote autoimmune inflammation
title_full_unstemmed	FGF2 cooperates with IL-17 to promote autoimmune inflammation
title_sort	fgf2 cooperates with il-17 to promote autoimmune inflammation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/73c7aea82a264b86b2b5961d19bf7011
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FGF2 cooperates with IL-17 to promote autoimmune inflammation

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