A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells

Abstract The selective and efficient monitoring of mercury (Hg2+) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8‐naphthalimide‐based fluorescent probe NADP for the detection of Hg2+ based on a fluorescence enhancement strategy has been designed and synthes...

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Autores principales:	Shaoyu Lei, Xia Meng, Dr. Lizhen Wang, Prof. Jianhua Zhou, Prof. Dawei Qin, Prof. Hongdong Duan
Formato:	article
Lenguaje:	EN
Publicado:	Wiley-VCH 2021
Materias:	cell imaging deprotection reactions mercury ions naphthalimide fluorescent probes Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/73c8176f269a4d4093e2cd5aa7320f56
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spelling	oai:doaj.org-article:73c8176f269a4d4093e2cd5aa7320f562021-11-27T06:12:47ZA Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells2191-136310.1002/open.202100204https://doaj.org/article/73c8176f269a4d4093e2cd5aa7320f562021-11-01T00:00:00Zhttps://doi.org/10.1002/open.202100204https://doaj.org/toc/2191-1363Abstract The selective and efficient monitoring of mercury (Hg2+) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8‐naphthalimide‐based fluorescent probe NADP for the detection of Hg2+ based on a fluorescence enhancement strategy has been designed and synthesized. The NADP probe can detect Hg2+ with high selectivity and sensitivity and a low detection limit of 13 nm. The detection mechanism was based on a Hg2+‐triggered deprotection reaction, resulting in a dramatic change in fluorescence from colorless to green at physiological pH. Most importantly, biological investigation has shown that the NADP probe can be successfully applied to the monitoring of Hg2+ in living cells and zebrafish with low cytotoxicity.Shaoyu LeiXia MengDr. Lizhen WangProf. Jianhua ZhouProf. Dawei QinProf. Hongdong DuanWiley-VCHarticlecell imagingdeprotection reactionsmercury ionsnaphthalimidefluorescent probesChemistryQD1-999ENChemistryOpen, Vol 10, Iss 11, Pp 1116-1122 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell imaging deprotection reactions mercury ions naphthalimide fluorescent probes Chemistry QD1-999
spellingShingle	cell imaging deprotection reactions mercury ions naphthalimide fluorescent probes Chemistry QD1-999 Shaoyu Lei Xia Meng Dr. Lizhen Wang Prof. Jianhua Zhou Prof. Dawei Qin Prof. Hongdong Duan A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells
description	Abstract The selective and efficient monitoring of mercury (Hg2+) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8‐naphthalimide‐based fluorescent probe NADP for the detection of Hg2+ based on a fluorescence enhancement strategy has been designed and synthesized. The NADP probe can detect Hg2+ with high selectivity and sensitivity and a low detection limit of 13 nm. The detection mechanism was based on a Hg2+‐triggered deprotection reaction, resulting in a dramatic change in fluorescence from colorless to green at physiological pH. Most importantly, biological investigation has shown that the NADP probe can be successfully applied to the monitoring of Hg2+ in living cells and zebrafish with low cytotoxicity.
format	article
author	Shaoyu Lei Xia Meng Dr. Lizhen Wang Prof. Jianhua Zhou Prof. Dawei Qin Prof. Hongdong Duan
author_facet	Shaoyu Lei Xia Meng Dr. Lizhen Wang Prof. Jianhua Zhou Prof. Dawei Qin Prof. Hongdong Duan
author_sort	Shaoyu Lei
title	A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells
title_short	A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells
title_full	A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells
title_fullStr	A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells
title_full_unstemmed	A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells
title_sort	naphthalimide‐based fluorescent probe for the detection and imaging of mercury ions in living cells
publisher	Wiley-VCH
publishDate	2021
url	https://doaj.org/article/73c8176f269a4d4093e2cd5aa7320f56
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A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells

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