From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments

A difficulty in encoding spatial information in an egocentric (i.e., body-to-object) and especially allocentric (i.e., object-to-object) manner, and impairments in executive function (EF) are typical in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). Since executive functions...

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Autores principales:	Tina Iachini, Francesco Ruotolo, Alessandro Iavarone, Michele Carpinelli Mazzi, Gennaro Ruggiero
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	visuo-spatial abilities frontal functions attentional resources egocentric/allocentric frames of reference healthy aging amnesic mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/73c9d1f226f1450ebc792e77f9149e14
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spelling	oai:doaj.org-article:73c9d1f226f1450ebc792e77f9149e142021-11-25T16:59:15ZFrom aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments10.3390/brainsci111115362076-3425https://doaj.org/article/73c9d1f226f1450ebc792e77f9149e142021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1536https://doaj.org/toc/2076-3425A difficulty in encoding spatial information in an egocentric (i.e., body-to-object) and especially allocentric (i.e., object-to-object) manner, and impairments in executive function (EF) are typical in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). Since executive functions are involved in spatial encodings, it is important to understand the extent of their reciprocal or selective impairment. To this end, AD patients, aMCI and healthy elderly people had to provide egocentric (What object was closest to you?) and allocentric (What object was closest to object X?) judgments about memorized objects. Participants’ frontal functions, attentional resources and visual-spatial memory were assessed with the Frontal Assessment Battery (FAB), the Trail Making Test (TMT) and the Corsi Block Tapping Test (forward/backward). Results showed that ADs performed worse than all others in all tasks but did not differ from aMCIs in allocentric judgments and Corsi forward. Regression analyses showed, although to different degrees in the three groups, a link between attentional resources, visuo-spatial memory and egocentric performance, and between frontal resources and allocentric performance. Therefore, visuo-spatial memory, especially when it involves allocentric frames and requires demanding active processing, should be carefully assessed to reveal early signs of conversion from aMCI to AD.Tina IachiniFrancesco RuotoloAlessandro IavaroneMichele Carpinelli MazziGennaro RuggieroMDPI AGarticlevisuo-spatial abilitiesfrontal functionsattentional resourcesegocentric/allocentric frames of referencehealthy agingamnesic mild cognitive impairmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1536, p 1536 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	visuo-spatial abilities frontal functions attentional resources egocentric/allocentric frames of reference healthy aging amnesic mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	visuo-spatial abilities frontal functions attentional resources egocentric/allocentric frames of reference healthy aging amnesic mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Tina Iachini Francesco Ruotolo Alessandro Iavarone Michele Carpinelli Mazzi Gennaro Ruggiero From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments
description	A difficulty in encoding spatial information in an egocentric (i.e., body-to-object) and especially allocentric (i.e., object-to-object) manner, and impairments in executive function (EF) are typical in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). Since executive functions are involved in spatial encodings, it is important to understand the extent of their reciprocal or selective impairment. To this end, AD patients, aMCI and healthy elderly people had to provide egocentric (What object was closest to you?) and allocentric (What object was closest to object X?) judgments about memorized objects. Participants’ frontal functions, attentional resources and visual-spatial memory were assessed with the Frontal Assessment Battery (FAB), the Trail Making Test (TMT) and the Corsi Block Tapping Test (forward/backward). Results showed that ADs performed worse than all others in all tasks but did not differ from aMCIs in allocentric judgments and Corsi forward. Regression analyses showed, although to different degrees in the three groups, a link between attentional resources, visuo-spatial memory and egocentric performance, and between frontal resources and allocentric performance. Therefore, visuo-spatial memory, especially when it involves allocentric frames and requires demanding active processing, should be carefully assessed to reveal early signs of conversion from aMCI to AD.
format	article
author	Tina Iachini Francesco Ruotolo Alessandro Iavarone Michele Carpinelli Mazzi Gennaro Ruggiero
author_facet	Tina Iachini Francesco Ruotolo Alessandro Iavarone Michele Carpinelli Mazzi Gennaro Ruggiero
author_sort	Tina Iachini
title	From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments
title_short	From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments
title_full	From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments
title_fullStr	From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments
title_full_unstemmed	From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments
title_sort	from amci to ad: the role of visuo-spatial memory span and executive functions in egocentric and allocentric spatial impairments
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/73c9d1f226f1450ebc792e77f9149e14
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From aMCI to AD: The Role of Visuo-Spatial Memory Span and Executive Functions in Egocentric and Allocentric Spatial Impairments

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