Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Bruno Fonseca-Santos, Aline Martins dos Santos, Camila Fernanda Rodero, Maria Palmira Daflon Gremião, Marlus Chorilli School of Pharmaceutical Sciences, UNESP – São Paulo State University, Araraquara, São Paulo Brazil Abstract: From previous studies, it h...

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Autores principales:	Fonseca-Santos B, dos Santos AM, Rodero CF, Gremião MPD, Chorilli M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Liquid crystal Surfactant-based system Topical drug delivery Bioadhesion Skin Anti-inflammatory Curcumin Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/73d2a7a88ab84539b94b5f89f23d92fe
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spelling	oai:doaj.org-article:73d2a7a88ab84539b94b5f89f23d92fe2021-12-02T02:45:54ZDesign, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery1178-2013https://doaj.org/article/73d2a7a88ab84539b94b5f89f23d92fe2016-09-01T00:00:00Zhttps://www.dovepress.com/design-characterization-and-biological-evaluation-of-curcumin-loaded-s-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bruno Fonseca-Santos, Aline Martins dos Santos, Camila Fernanda Rodero, Maria Palmira Daflon Gremião, Marlus Chorilli School of Pharmaceutical Sciences, UNESP – São Paulo State University, Araraquara, São Paulo Brazil Abstract: From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G'>G''), as evidenced by the increased G' values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin. Keywords: lamellar mesophase, hexagonal mesophase, liquid crystalline mesophase, self-assembly structures, water-surfactant-oil based-structures, curcumin, paw edemaFonseca-Santos Bdos Santos AMRodero CFGremião MPDChorilli MDove Medical PressarticleLiquid crystalSurfactant-based systemTopical drug deliveryBioadhesionSkinAnti-inflammatoryCurcuminMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4553-4562 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Liquid crystal Surfactant-based system Topical drug delivery Bioadhesion Skin Anti-inflammatory Curcumin Medicine (General) R5-920
spellingShingle	Liquid crystal Surfactant-based system Topical drug delivery Bioadhesion Skin Anti-inflammatory Curcumin Medicine (General) R5-920 Fonseca-Santos B dos Santos AM Rodero CF Gremião MPD Chorilli M Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery
description	Bruno Fonseca-Santos, Aline Martins dos Santos, Camila Fernanda Rodero, Maria Palmira Daflon Gremião, Marlus Chorilli School of Pharmaceutical Sciences, UNESP – São Paulo State University, Araraquara, São Paulo Brazil Abstract: From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G'>G''), as evidenced by the increased G' values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin. Keywords: lamellar mesophase, hexagonal mesophase, liquid crystalline mesophase, self-assembly structures, water-surfactant-oil based-structures, curcumin, paw edema
format	article
author	Fonseca-Santos B dos Santos AM Rodero CF Gremião MPD Chorilli M
author_facet	Fonseca-Santos B dos Santos AM Rodero CF Gremião MPD Chorilli M
author_sort	Fonseca-Santos B
title	Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery
title_short	Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery
title_full	Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery
title_fullStr	Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery
title_full_unstemmed	Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery
title_sort	design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/73d2a7a88ab84539b94b5f89f23d92fe
work_keys_str_mv	AT fonsecasantosb designcharacterizationandbiologicalevaluationofcurcuminloadedsurfactantbasedsystemsfortopicaldrugdelivery AT dossantosam designcharacterizationandbiologicalevaluationofcurcuminloadedsurfactantbasedsystemsfortopicaldrugdelivery AT roderocf designcharacterizationandbiologicalevaluationofcurcuminloadedsurfactantbasedsystemsfortopicaldrugdelivery AT gremiatildeompd designcharacterizationandbiologicalevaluationofcurcuminloadedsurfactantbasedsystemsfortopicaldrugdelivery AT chorillim designcharacterizationandbiologicalevaluationofcurcuminloadedsurfactantbasedsystemsfortopicaldrugdelivery
_version_	1718402167482613760

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

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