Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.
Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escap...
Guardado en:
Autores principales: | Ryan M Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W Krizan, Awet Abraha, Denis M Tebit, Hong Zhao, Santiago Avila, Michael A Lobritz, M Juliana McElrath, Sylvie Le Gall, James I Mullins, Eric J Arts |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2009
|
Materias: | |
Acceso en línea: | https://doaj.org/article/73d3c53637944733899bd6ed54aaad98 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.
por: Jonathan M Carlson, et al.
Publicado: (2008) -
CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.
por: Sylvain Cardinaud, et al.
Publicado: (2011) -
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
por: Denis R Chopera, et al.
Publicado: (2008) -
Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
por: Roxana Khazen, et al.
Publicado: (2016) -
Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes
por: Yushen Du, et al.
Publicado: (2017)