Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.

Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escap...

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Bibliographic Details
Main Authors: Ryan M Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W Krizan, Awet Abraha, Denis M Tebit, Hong Zhao, Santiago Avila, Michael A Lobritz, M Juliana McElrath, Sylvie Le Gall, James I Mullins, Eric J Arts
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2009
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/73d3c53637944733899bd6ed54aaad98
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