A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensit...
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Nature Portfolio
2018
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oai:doaj.org-article:73d56573bdd642718c8b15d27f8152fb2021-12-02T17:32:29ZA hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival10.1038/s41467-018-07201-12041-1723https://doaj.org/article/73d56573bdd642718c8b15d27f8152fb2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07201-1https://doaj.org/toc/2041-1723Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.Ting ZhouTae Wan KimChi Nok ChongLei TanSadaf AminZohreh Sadat BadieyanSuranjit MukherjeeZaniar GhazizadehHui ZengMin GuoMiguel CrespoTuo ZhangReyn KenyonChristopher L. RobinsonEffie ApostolouHui WangJenny Zhaoying XiangTodd EvansLorenz StuderShuibing ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ting Zhou Tae Wan Kim Chi Nok Chong Lei Tan Sadaf Amin Zohreh Sadat Badieyan Suranjit Mukherjee Zaniar Ghazizadeh Hui Zeng Min Guo Miguel Crespo Tuo Zhang Reyn Kenyon Christopher L. Robinson Effie Apostolou Hui Wang Jenny Zhaoying Xiang Todd Evans Lorenz Studer Shuibing Chen A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival |
| description |
Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity. |
| format |
article |
| author |
Ting Zhou Tae Wan Kim Chi Nok Chong Lei Tan Sadaf Amin Zohreh Sadat Badieyan Suranjit Mukherjee Zaniar Ghazizadeh Hui Zeng Min Guo Miguel Crespo Tuo Zhang Reyn Kenyon Christopher L. Robinson Effie Apostolou Hui Wang Jenny Zhaoying Xiang Todd Evans Lorenz Studer Shuibing Chen |
| author_facet |
Ting Zhou Tae Wan Kim Chi Nok Chong Lei Tan Sadaf Amin Zohreh Sadat Badieyan Suranjit Mukherjee Zaniar Ghazizadeh Hui Zeng Min Guo Miguel Crespo Tuo Zhang Reyn Kenyon Christopher L. Robinson Effie Apostolou Hui Wang Jenny Zhaoying Xiang Todd Evans Lorenz Studer Shuibing Chen |
| author_sort |
Ting Zhou |
| title |
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival |
| title_short |
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival |
| title_full |
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival |
| title_fullStr |
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival |
| title_full_unstemmed |
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival |
| title_sort |
hpsc-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/73d56573bdd642718c8b15d27f8152fb |
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