Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma

Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume i...

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Autores principales:	Andrew Li, Hiang Ping Chan, Phyllis X.L. Gan, Mei Fong Liew, W.S. Fred Wong, Hui-Fang Lim
Formato:	article
Lenguaje:	EN
Publicado:	The Korean Association of Internal Medicine 2021
Materias:	pulmonary disease chronic obstructive inhaled corticosteroids eosinophilia Medicine R
Acceso en línea:	https://doaj.org/article/73dee75f007948f68c61dda89afb3cae
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spelling	oai:doaj.org-article:73dee75f007948f68c61dda89afb3cae2021-11-08T00:59:06ZEosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma1226-33032005-664810.3904/kjim.2021.180https://doaj.org/article/73dee75f007948f68c61dda89afb3cae2021-11-01T00:00:00Zhttp://www.kjim.org/upload/pdf/kjim-2021-180.pdfhttps://doaj.org/toc/1226-3303https://doaj.org/toc/2005-6648Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume in the 1st second. Importantly, this endotype is a marker of treat ment responsiveness to inhaled corticosteroid (ICS), resulting in decreased mortality risk. In this review, we highlight differences in the biology of eosinophils in COPD compared to asthma and the different definitions of the COPD eosinophilic endotype based on sputum and blood eosinophil count (BEC) with the corresponding limitations. Although BEC is useful as a biomarker for eosinophilic COPD endotype, optimal BEC cut-offs can be combined with clinical characteristics to improve its sensitivity and specificity. A targeted approach comprising airway eosinophilia and appropriate clinical and physiological features may improve identification of subgroups of patients who would benefit from biologic therapy or early use of ICS for disease modification.Andrew LiHiang Ping ChanPhyllis X.L. GanMei Fong LiewW.S. Fred WongHui-Fang LimThe Korean Association of Internal Medicinearticlepulmonary diseasechronic obstructiveinhaled corticosteroidseosinophiliaMedicineRENThe Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1305-1319 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulmonary disease chronic obstructive inhaled corticosteroids eosinophilia Medicine R
spellingShingle	pulmonary disease chronic obstructive inhaled corticosteroids eosinophilia Medicine R Andrew Li Hiang Ping Chan Phyllis X.L. Gan Mei Fong Liew W.S. Fred Wong Hui-Fang Lim Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
description	Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume in the 1st second. Importantly, this endotype is a marker of treat ment responsiveness to inhaled corticosteroid (ICS), resulting in decreased mortality risk. In this review, we highlight differences in the biology of eosinophils in COPD compared to asthma and the different definitions of the COPD eosinophilic endotype based on sputum and blood eosinophil count (BEC) with the corresponding limitations. Although BEC is useful as a biomarker for eosinophilic COPD endotype, optimal BEC cut-offs can be combined with clinical characteristics to improve its sensitivity and specificity. A targeted approach comprising airway eosinophilia and appropriate clinical and physiological features may improve identification of subgroups of patients who would benefit from biologic therapy or early use of ICS for disease modification.
format	article
author	Andrew Li Hiang Ping Chan Phyllis X.L. Gan Mei Fong Liew W.S. Fred Wong Hui-Fang Lim
author_facet	Andrew Li Hiang Ping Chan Phyllis X.L. Gan Mei Fong Liew W.S. Fred Wong Hui-Fang Lim
author_sort	Andrew Li
title	Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
title_short	Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
title_full	Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
title_fullStr	Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
title_full_unstemmed	Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
title_sort	eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
publisher	The Korean Association of Internal Medicine
publishDate	2021
url	https://doaj.org/article/73dee75f007948f68c61dda89afb3cae
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Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma

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