The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome

Abstract At present, prognostic biomarkers of acute coronary syndrome (ACS) are fewer. The aim of this study was to explore the predictive value of soluble osteoclast-associated receptor (sOSCAR) level for the major adverse cardiovascular events (MACE) occurring within 30 days after ACS. From Januar...

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Autores principales:	Rong Wang, Jing Wang, Ling Xie, Hong-li Cai, Yi Zhang, Qing Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73df01dadf6248cdbdb117096dc19214
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spelling	oai:doaj.org-article:73df01dadf6248cdbdb117096dc192142021-12-02T15:03:13ZThe predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome10.1038/s41598-021-91054-02045-2322https://doaj.org/article/73df01dadf6248cdbdb117096dc192142021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91054-0https://doaj.org/toc/2045-2322Abstract At present, prognostic biomarkers of acute coronary syndrome (ACS) are fewer. The aim of this study was to explore the predictive value of soluble osteoclast-associated receptor (sOSCAR) level for the major adverse cardiovascular events (MACE) occurring within 30 days after ACS. From January to August 2020, a total of 108 patients with ACS who were admitted to our hospital, were enrolled in this study. Of the 108 patients, 79 were men and 29 women. Patient-related data, including age, sex, body mass index, history of type 2 diabetes, history of hyperlipidemia and serum sOSCAR level, were collected. All patients were followed up for 30 days. Based on MACE occurrence, the 108 patients were divided into MACE group (n = 17) and non-MACE group (n = 91). The baseline data were compared between the two groups, MACE-independent risk factors were identified by multivariate regression analysis, and the predictive value of sOSCAR for MACE occurring within 30 days after CAS was analyzed using receiver operating characteristic (ROC) curve. At the same time, according to the type of ACS, the 108 patients with ACS were divided into unstable angina (UA) group (n = 29), non ST-segment elevation myocardial infarction (USTEMI) group (n = 45) and ST-segment elevation myocardial infarction (STEMI) group (n = 34), and then the sOSCAR level and MACE incidence were observed in each group. The serum sOSCAR level was significantly lower in the MACE group [130(100,183)] than in the non-MACE group [301(220,370)] (P = 0.000). The area under ROC curve of sOSCAR level for MACE occurring within 30 days after CAS was 0.860 with 95%CI 0.782–0.919, P < 0.001. Multivariate regression analysis indicated that the sOSCAR level was an independent risk factor for the MACE occurring within 30 days after CAS (OR 0.26, 95%CI 0.087–0.777, P = 0.04). The MACE incidence (0%) was the lowest but the sOSCAR level was the highest in the UA group, while in the STEMI group, the MACE incidence (23.53%) was the higest but the sOSCAR level was the lowest among the UA, STEMI and NSTEMI groups. Serum sOSCAR level may be used as a predictor of MACE occurring within the short-term after ACS. The higher the sOSCAR level, the lower the MACE incidence.Rong WangJing WangLing XieHong-li CaiYi ZhangQing ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rong Wang Jing Wang Ling Xie Hong-li Cai Yi Zhang Qing Zhang The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome
description	Abstract At present, prognostic biomarkers of acute coronary syndrome (ACS) are fewer. The aim of this study was to explore the predictive value of soluble osteoclast-associated receptor (sOSCAR) level for the major adverse cardiovascular events (MACE) occurring within 30 days after ACS. From January to August 2020, a total of 108 patients with ACS who were admitted to our hospital, were enrolled in this study. Of the 108 patients, 79 were men and 29 women. Patient-related data, including age, sex, body mass index, history of type 2 diabetes, history of hyperlipidemia and serum sOSCAR level, were collected. All patients were followed up for 30 days. Based on MACE occurrence, the 108 patients were divided into MACE group (n = 17) and non-MACE group (n = 91). The baseline data were compared between the two groups, MACE-independent risk factors were identified by multivariate regression analysis, and the predictive value of sOSCAR for MACE occurring within 30 days after CAS was analyzed using receiver operating characteristic (ROC) curve. At the same time, according to the type of ACS, the 108 patients with ACS were divided into unstable angina (UA) group (n = 29), non ST-segment elevation myocardial infarction (USTEMI) group (n = 45) and ST-segment elevation myocardial infarction (STEMI) group (n = 34), and then the sOSCAR level and MACE incidence were observed in each group. The serum sOSCAR level was significantly lower in the MACE group [130(100,183)] than in the non-MACE group [301(220,370)] (P = 0.000). The area under ROC curve of sOSCAR level for MACE occurring within 30 days after CAS was 0.860 with 95%CI 0.782–0.919, P < 0.001. Multivariate regression analysis indicated that the sOSCAR level was an independent risk factor for the MACE occurring within 30 days after CAS (OR 0.26, 95%CI 0.087–0.777, P = 0.04). The MACE incidence (0%) was the lowest but the sOSCAR level was the highest in the UA group, while in the STEMI group, the MACE incidence (23.53%) was the higest but the sOSCAR level was the lowest among the UA, STEMI and NSTEMI groups. Serum sOSCAR level may be used as a predictor of MACE occurring within the short-term after ACS. The higher the sOSCAR level, the lower the MACE incidence.
format	article
author	Rong Wang Jing Wang Ling Xie Hong-li Cai Yi Zhang Qing Zhang
author_facet	Rong Wang Jing Wang Ling Xie Hong-li Cai Yi Zhang Qing Zhang
author_sort	Rong Wang
title	The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome
title_short	The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome
title_full	The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome
title_fullStr	The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome
title_full_unstemmed	The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome
title_sort	predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/73df01dadf6248cdbdb117096dc19214
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The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome

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