APOE gene polymorphism in long-lived individuals from a central China population

Abstract Previous studies from European and East Asian cohorts reported conflicting results over whether and how the frequencies of the three common alleles, ε2, ε3 and ε4, of the apolioprotein E gene (APOE), in long-lived individuals differ from those in younger age groups. This study was the first...

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Autores principales:	Guodong Liu, Xiang Liu, Pulin Yu, Qi Wang, Hua Wang, Chenfang Li, Guangming Ye, Xiaoling Wu, Chunling Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73e1bce75a604936aab51ce050b339a2
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spelling	oai:doaj.org-article:73e1bce75a604936aab51ce050b339a22021-12-02T12:30:26ZAPOE gene polymorphism in long-lived individuals from a central China population10.1038/s41598-017-03227-52045-2322https://doaj.org/article/73e1bce75a604936aab51ce050b339a22017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03227-5https://doaj.org/toc/2045-2322Abstract Previous studies from European and East Asian cohorts reported conflicting results over whether and how the frequencies of the three common alleles, ε2, ε3 and ε4, of the apolioprotein E gene (APOE), in long-lived individuals differ from those in younger age groups. This study was the first to analyse these frequencies of long-lived individuals from central China. Genotyping of APOE alleles and genotypes was carried out in 70 long-lived individuals and 204 younger controls. No difference in the frequency of any APOE allele or genotype was found between the long-lived participants and their younger controls, but the long-lived group seemed to have a higher ε4 frequency (15.71%) than the 24–50 and 51–75 age groups (10.2% and 11.32%, P > 0.05). Notably, when compared with two other Chinese studies, the central China long-lived group had a higher ε4 frequency than its southern and eastern China counterparts (15.71% vs. 2.82% and 2.54%, P < 0.05). It is not clear to what extent population substructure or lifestyles contributed to these divergent findings. A clear understanding of the contribution of APOE polymorphisms to longevity in the Han Chinese population may be achieved only through large scale studies with participants from well-defined regional clusters.Guodong LiuXiang LiuPulin YuQi WangHua WangChenfang LiGuangming YeXiaoling WuChunling TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guodong Liu Xiang Liu Pulin Yu Qi Wang Hua Wang Chenfang Li Guangming Ye Xiaoling Wu Chunling Tan APOE gene polymorphism in long-lived individuals from a central China population
description	Abstract Previous studies from European and East Asian cohorts reported conflicting results over whether and how the frequencies of the three common alleles, ε2, ε3 and ε4, of the apolioprotein E gene (APOE), in long-lived individuals differ from those in younger age groups. This study was the first to analyse these frequencies of long-lived individuals from central China. Genotyping of APOE alleles and genotypes was carried out in 70 long-lived individuals and 204 younger controls. No difference in the frequency of any APOE allele or genotype was found between the long-lived participants and their younger controls, but the long-lived group seemed to have a higher ε4 frequency (15.71%) than the 24–50 and 51–75 age groups (10.2% and 11.32%, P > 0.05). Notably, when compared with two other Chinese studies, the central China long-lived group had a higher ε4 frequency than its southern and eastern China counterparts (15.71% vs. 2.82% and 2.54%, P < 0.05). It is not clear to what extent population substructure or lifestyles contributed to these divergent findings. A clear understanding of the contribution of APOE polymorphisms to longevity in the Han Chinese population may be achieved only through large scale studies with participants from well-defined regional clusters.
format	article
author	Guodong Liu Xiang Liu Pulin Yu Qi Wang Hua Wang Chenfang Li Guangming Ye Xiaoling Wu Chunling Tan
author_facet	Guodong Liu Xiang Liu Pulin Yu Qi Wang Hua Wang Chenfang Li Guangming Ye Xiaoling Wu Chunling Tan
author_sort	Guodong Liu
title	APOE gene polymorphism in long-lived individuals from a central China population
title_short	APOE gene polymorphism in long-lived individuals from a central China population
title_full	APOE gene polymorphism in long-lived individuals from a central China population
title_fullStr	APOE gene polymorphism in long-lived individuals from a central China population
title_full_unstemmed	APOE gene polymorphism in long-lived individuals from a central China population
title_sort	apoe gene polymorphism in long-lived individuals from a central china population
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/73e1bce75a604936aab51ce050b339a2
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APOE gene polymorphism in long-lived individuals from a central China population

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