CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function

CD40L-expressing chimeric antigen receptor (CAR) T cells show enhanced anti-tumor immunity, but the cellular mechanisms are still unclear. Here we show, by analyzing mice deficient of conventional dendritic cell type 1 (cDC1) that cDC1s are induced by CD40L+ CAR T cells to prime endogenous CD8 T cel...

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Auteurs principaux:	Nicholas F. Kuhn, Andrea V. Lopez, Xinghuo Li, Winson Cai, Anthony F. Daniyan, Renier J. Brentjens
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/73e25f98128942e1a7488cf2c4e6a8e9
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id	oai:doaj.org-article:73e25f98128942e1a7488cf2c4e6a8e9
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spelling	oai:doaj.org-article:73e25f98128942e1a7488cf2c4e6a8e92021-12-02T14:41:13ZCD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function10.1038/s41467-020-19833-32041-1723https://doaj.org/article/73e25f98128942e1a7488cf2c4e6a8e92020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19833-3https://doaj.org/toc/2041-1723CD40L-expressing chimeric antigen receptor (CAR) T cells show enhanced anti-tumor immunity, but the cellular mechanisms are still unclear. Here we show, by analyzing mice deficient of conventional dendritic cell type 1 (cDC1) that cDC1s are induced by CD40L+ CAR T cells to prime endogenous CD8 T cells for a stronger anti-tumor immune response.Nicholas F. KuhnAndrea V. LopezXinghuo LiWinson CaiAnthony F. DaniyanRenier J. BrentjensNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas F. Kuhn Andrea V. Lopez Xinghuo Li Winson Cai Anthony F. Daniyan Renier J. Brentjens CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
description	CD40L-expressing chimeric antigen receptor (CAR) T cells show enhanced anti-tumor immunity, but the cellular mechanisms are still unclear. Here we show, by analyzing mice deficient of conventional dendritic cell type 1 (cDC1) that cDC1s are induced by CD40L+ CAR T cells to prime endogenous CD8 T cells for a stronger anti-tumor immune response.
format	article
author	Nicholas F. Kuhn Andrea V. Lopez Xinghuo Li Winson Cai Anthony F. Daniyan Renier J. Brentjens
author_facet	Nicholas F. Kuhn Andrea V. Lopez Xinghuo Li Winson Cai Anthony F. Daniyan Renier J. Brentjens
author_sort	Nicholas F. Kuhn
title	CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
title_short	CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
title_full	CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
title_fullStr	CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
title_full_unstemmed	CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
title_sort	cd103+ cdc1 and endogenous cd8+ t cells are necessary for improved cd40l-overexpressing car t cell antitumor function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/73e25f98128942e1a7488cf2c4e6a8e9
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CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function

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