Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)

Background Obstructive lung disease is a significant cause of morbidity and healthcare burden within the USA. A growing body of evidence has suggested that vitamin D levels can influence the course or incidence of obstructive lung disease. However, there is an insufficient previous investigation of...

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Autores principales:	Mohamed Ismail Seedahmed, Aaron D Baugh, Jordan A Kempker
Formato:	article
Lenguaje:	EN
Publicado:	BMJ Publishing Group 2020
Materias:	Medicine R Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/73e52eba5abe49bfa1b691cdc8881b10
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spelling	oai:doaj.org-article:73e52eba5abe49bfa1b691cdc8881b102021-11-17T05:30:04ZHigher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)10.1136/bmjresp-2020-0007982052-4439https://doaj.org/article/73e52eba5abe49bfa1b691cdc8881b102020-12-01T00:00:00Zhttps://bmjopenrespres.bmj.com/content/7/1/e000798.fullhttps://doaj.org/toc/2052-4439Background Obstructive lung disease is a significant cause of morbidity and healthcare burden within the USA. A growing body of evidence has suggested that vitamin D levels can influence the course or incidence of obstructive lung disease. However, there is an insufficient previous investigation of this association.Study design and methods We used the National Health and Nutrition Examination Survey (NHANES) cycles 2007–2008 and 2009–2010 spirometry results of individuals aged 40 years and older to assess the association between serum 25-hydroxyvitamin D levels and obstructive lung disease, as defined by the American Thoracic Society using the lower limit of normal. We used stage multivariate survey-logistic regression.Results The final model included age, gender, body mass index, pack-years smoking history, season, income-to-poverty ratio and race/ethnicity. In the primary analysis using vitamin D as a continuous variable, there was no association between vitamin D levels and obstructive lung disease. We noted a trend between ‘other Hispanic’ self-identified race and serum vitamin D levels wherein higher levels were associated with higher odds of obstructive lung disease in this ethnicity, but not among other racial or ethnic groups (OR (95% CI)=1.40 (0.98 to 1.99), p=0.06). In a secondary analysis, when vitamin D was measured as a categorical variable, there was a significant association between the highest levels of serum vitamin D levels and lesser odds of obstructive lung disease (OR (95% CI)=0.77 [0.61 to 0.98], p=0.04).Conclusions Higher serum vitamin D levels among adults are associated with decreased odds of obstructive lung disease in the general population. Results among non-Mexican Hispanic participants highlight the need for further research in minority populations. More work is needed to address the course and incidence of lung disease in the USA.Mohamed Ismail SeedahmedAaron D BaughJordan A KempkerBMJ Publishing GrouparticleMedicineRDiseases of the respiratory systemRC705-779ENBMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Diseases of the respiratory system RC705-779
spellingShingle	Medicine R Diseases of the respiratory system RC705-779 Mohamed Ismail Seedahmed Aaron D Baugh Jordan A Kempker Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)
description	Background Obstructive lung disease is a significant cause of morbidity and healthcare burden within the USA. A growing body of evidence has suggested that vitamin D levels can influence the course or incidence of obstructive lung disease. However, there is an insufficient previous investigation of this association.Study design and methods We used the National Health and Nutrition Examination Survey (NHANES) cycles 2007–2008 and 2009–2010 spirometry results of individuals aged 40 years and older to assess the association between serum 25-hydroxyvitamin D levels and obstructive lung disease, as defined by the American Thoracic Society using the lower limit of normal. We used stage multivariate survey-logistic regression.Results The final model included age, gender, body mass index, pack-years smoking history, season, income-to-poverty ratio and race/ethnicity. In the primary analysis using vitamin D as a continuous variable, there was no association between vitamin D levels and obstructive lung disease. We noted a trend between ‘other Hispanic’ self-identified race and serum vitamin D levels wherein higher levels were associated with higher odds of obstructive lung disease in this ethnicity, but not among other racial or ethnic groups (OR (95% CI)=1.40 (0.98 to 1.99), p=0.06). In a secondary analysis, when vitamin D was measured as a categorical variable, there was a significant association between the highest levels of serum vitamin D levels and lesser odds of obstructive lung disease (OR (95% CI)=0.77 [0.61 to 0.98], p=0.04).Conclusions Higher serum vitamin D levels among adults are associated with decreased odds of obstructive lung disease in the general population. Results among non-Mexican Hispanic participants highlight the need for further research in minority populations. More work is needed to address the course and incidence of lung disease in the USA.
format	article
author	Mohamed Ismail Seedahmed Aaron D Baugh Jordan A Kempker
author_facet	Mohamed Ismail Seedahmed Aaron D Baugh Jordan A Kempker
author_sort	Mohamed Ismail Seedahmed
title	Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)
title_short	Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)
title_full	Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)
title_fullStr	Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)
title_full_unstemmed	Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)
title_sort	higher serum vitamin d levels are associated with decreased odds of obstructive lung disease in the general population: an nhanes analysis (2007–2008 to 2009–2010)
publisher	BMJ Publishing Group
publishDate	2020
url	https://doaj.org/article/73e52eba5abe49bfa1b691cdc8881b10
work_keys_str_mv	AT mohamedismailseedahmed higherserumvitamindlevelsareassociatedwithdecreasedoddsofobstructivelungdiseaseinthegeneralpopulationannhanesanalysis20072008to20092010 AT aarondbaugh higherserumvitamindlevelsareassociatedwithdecreasedoddsofobstructivelungdiseaseinthegeneralpopulationannhanesanalysis20072008to20092010 AT jordanakempker higherserumvitamindlevelsareassociatedwithdecreasedoddsofobstructivelungdiseaseinthegeneralpopulationannhanesanalysis20072008to20092010
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Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)

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