Restoration of high-sensitivity and adapting vision with a cone opsin

Activating the spared neurons downstream of rods and cones is a potential therapeutic approach for retinal degeneration, but has been limited by the characteristics of the opsins available. Here, the authors use medium wavelength cone opsin which has faster kinetics than others and show that it reso...

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Autores principales:	Michael H. Berry, Amy Holt, Autoosa Salari, Julia Veit, Meike Visel, Joshua Levitz, Krisha Aghi, Benjamin M. Gaub, Benjamin Sivyer, John G. Flannery, Ehud Y. Isacoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73e80c971db748c985115ccc7728f498
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spelling	oai:doaj.org-article:73e80c971db748c985115ccc7728f4982021-12-02T17:31:22ZRestoration of high-sensitivity and adapting vision with a cone opsin10.1038/s41467-019-09124-x2041-1723https://doaj.org/article/73e80c971db748c985115ccc7728f4982019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09124-xhttps://doaj.org/toc/2041-1723Activating the spared neurons downstream of rods and cones is a potential therapeutic approach for retinal degeneration, but has been limited by the characteristics of the opsins available. Here, the authors use medium wavelength cone opsin which has faster kinetics than others and show that it resolves some of these difficulties in a mouse model.Michael H. BerryAmy HoltAutoosa SalariJulia VeitMeike ViselJoshua LevitzKrisha AghiBenjamin M. GaubBenjamin SivyerJohn G. FlanneryEhud Y. IsacoffNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael H. Berry Amy Holt Autoosa Salari Julia Veit Meike Visel Joshua Levitz Krisha Aghi Benjamin M. Gaub Benjamin Sivyer John G. Flannery Ehud Y. Isacoff Restoration of high-sensitivity and adapting vision with a cone opsin
description	Activating the spared neurons downstream of rods and cones is a potential therapeutic approach for retinal degeneration, but has been limited by the characteristics of the opsins available. Here, the authors use medium wavelength cone opsin which has faster kinetics than others and show that it resolves some of these difficulties in a mouse model.
format	article
author	Michael H. Berry Amy Holt Autoosa Salari Julia Veit Meike Visel Joshua Levitz Krisha Aghi Benjamin M. Gaub Benjamin Sivyer John G. Flannery Ehud Y. Isacoff
author_facet	Michael H. Berry Amy Holt Autoosa Salari Julia Veit Meike Visel Joshua Levitz Krisha Aghi Benjamin M. Gaub Benjamin Sivyer John G. Flannery Ehud Y. Isacoff
author_sort	Michael H. Berry
title	Restoration of high-sensitivity and adapting vision with a cone opsin
title_short	Restoration of high-sensitivity and adapting vision with a cone opsin
title_full	Restoration of high-sensitivity and adapting vision with a cone opsin
title_fullStr	Restoration of high-sensitivity and adapting vision with a cone opsin
title_full_unstemmed	Restoration of high-sensitivity and adapting vision with a cone opsin
title_sort	restoration of high-sensitivity and adapting vision with a cone opsin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/73e80c971db748c985115ccc7728f498
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Restoration of high-sensitivity and adapting vision with a cone opsin

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