ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY

Objective: To evaluate the success rate of injection ‘methotrexate’ in the management of ectopic pregnancy. Study Design: A single group interventional study. Place and Duration of Study: NESCOM Hospital Islamabad, from Jan 2014 to Dec 2017. Methodology: All patients admitted with ectopic p...

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Autores principales:	Mussarat Sultana, Saima Perveen, Sadia Kashif, Huma Karamat, Fasih Hashmi
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	ectopic pregnancy methotrexate βhcg level Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/73ecb0b30da3419eafc6aa9904db0d04
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spelling	oai:doaj.org-article:73ecb0b30da3419eafc6aa9904db0d042021-12-02T17:18:25ZROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY0030-96482411-8842https://doaj.org/article/73ecb0b30da3419eafc6aa9904db0d042020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5554https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the success rate of injection ‘methotrexate’ in the management of ectopic pregnancy. Study Design: A single group interventional study. Place and Duration of Study: NESCOM Hospital Islamabad, from Jan 2014 to Dec 2017. Methodology: All patients admitted with ectopic pregnancy fulfilling the inclusion criteria i.e, a stable clinical condition, no evidence of rupture on ultrasound, normal liver and renal functions were included in the study, while the patients who were showing signs of rupture ectopic or with abnormal liver and renal functions were excluded from the study. Data was collected on predesigned performa. Diagnostic tools were Transvaginal Sonography and serial serum β-human chorionic gonadotropin levels .These patients were treated with injection methotrexate 50 mg/kg body weight. Serum β-human chorionic gonadotropin levels were done on day 4 and day 7 and weekly thereafter till ≤5 mIU/ml. Results: The total number of patients (88) with 18-39 years, fulfilling the inclusion criteria were given injection methotrexate. Medical treatment was successful in 81.8% of patients whereas failure was observed in 18.2%. Among which 67 patients were given single dose, 20 patients received 2 doses and only 01 patient needed 3 doses. The mean resolution time for β-human chorionic gonadotropin level was 21 days (11-58). Average resolution time for adnexal masses (<3cm) was 19 days and for adnexal masses (>3cm) was 39 days. Conclusion: Methotrexate was found to be safe, cost effective and fertility preserving alternative to the surgical management of ectopic pregnancy.Mussarat SultanaSaima PerveenSadia KashifHuma KaramatFasih HashmiArmy Medical College Rawalpindiarticleectopic pregnancymethotrexateβhcg levelMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1305-1309 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ectopic pregnancy methotrexate βhcg level Medicine R Medicine (General) R5-920
spellingShingle	ectopic pregnancy methotrexate βhcg level Medicine R Medicine (General) R5-920 Mussarat Sultana Saima Perveen Sadia Kashif Huma Karamat Fasih Hashmi ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY
description	Objective: To evaluate the success rate of injection ‘methotrexate’ in the management of ectopic pregnancy. Study Design: A single group interventional study. Place and Duration of Study: NESCOM Hospital Islamabad, from Jan 2014 to Dec 2017. Methodology: All patients admitted with ectopic pregnancy fulfilling the inclusion criteria i.e, a stable clinical condition, no evidence of rupture on ultrasound, normal liver and renal functions were included in the study, while the patients who were showing signs of rupture ectopic or with abnormal liver and renal functions were excluded from the study. Data was collected on predesigned performa. Diagnostic tools were Transvaginal Sonography and serial serum β-human chorionic gonadotropin levels .These patients were treated with injection methotrexate 50 mg/kg body weight. Serum β-human chorionic gonadotropin levels were done on day 4 and day 7 and weekly thereafter till ≤5 mIU/ml. Results: The total number of patients (88) with 18-39 years, fulfilling the inclusion criteria were given injection methotrexate. Medical treatment was successful in 81.8% of patients whereas failure was observed in 18.2%. Among which 67 patients were given single dose, 20 patients received 2 doses and only 01 patient needed 3 doses. The mean resolution time for β-human chorionic gonadotropin level was 21 days (11-58). Average resolution time for adnexal masses (<3cm) was 19 days and for adnexal masses (>3cm) was 39 days. Conclusion: Methotrexate was found to be safe, cost effective and fertility preserving alternative to the surgical management of ectopic pregnancy.
format	article
author	Mussarat Sultana Saima Perveen Sadia Kashif Huma Karamat Fasih Hashmi
author_facet	Mussarat Sultana Saima Perveen Sadia Kashif Huma Karamat Fasih Hashmi
author_sort	Mussarat Sultana
title	ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY
title_short	ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY
title_full	ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY
title_fullStr	ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY
title_full_unstemmed	ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY
title_sort	role of injection methotrexate in the management of ectopic pregnancy
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/73ecb0b30da3419eafc6aa9904db0d04
work_keys_str_mv	AT mussaratsultana roleofinjectionmethotrexateinthemanagementofectopicpregnancy AT saimaperveen roleofinjectionmethotrexateinthemanagementofectopicpregnancy AT sadiakashif roleofinjectionmethotrexateinthemanagementofectopicpregnancy AT humakaramat roleofinjectionmethotrexateinthemanagementofectopicpregnancy AT fasihhashmi roleofinjectionmethotrexateinthemanagementofectopicpregnancy
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ROLE OF INJECTION METHOTREXATE IN THE MANAGEMENT OF ECTOPIC PREGNANCY

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