βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity

βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity

Ghosh et al. show that a lens protein βA1-crystallin inhibits PTP1B activity, regulating the metabolism of retinal astrocytes. They find that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in mice, suggesting the possibility that the interactio...

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Autores principales: Sayan Ghosh, Haitao Liu, Meysam Yazdankhah, Nadezda Stepicheva, Peng Shang, Tanuja Vaidya, Stacey Hose, Urvi Gupta, Michael Joseph Calderon, Ming-Wen Hu, Archana Padmanabhan Nair, Joseph Weiss, Christopher S. Fitting, Imran A. Bhutto, Santosh Gopi Krishna Gadde, Naveen Kumar Naik, Chaitra Jaydev, Gerard A. Lutty, James T. Handa, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, Dhivyaa Rajasundaram, Yuri Sergeev, J. Samuel Zigler, Swaminathan Sethu, Simon Watkins, Arkasubhra Ghosh, Debasish Sinha
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/73f2d2042a5b442cb0991f9ae494dfe7
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spelling oai:doaj.org-article:73f2d2042a5b442cb0991f9ae494dfe72021-12-02T13:34:31ZβA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity10.1038/s42003-021-01763-52399-3642https://doaj.org/article/73f2d2042a5b442cb0991f9ae494dfe72021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01763-5https://doaj.org/toc/2399-3642Ghosh et al. show that a lens protein βA1-crystallin inhibits PTP1B activity, regulating the metabolism of retinal astrocytes. They find that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in mice, suggesting the possibility that the interaction between βA1-PTP1B may be targeted for diabetic retinopathy.Sayan GhoshHaitao LiuMeysam YazdankhahNadezda StepichevaPeng ShangTanuja VaidyaStacey HoseUrvi GuptaMichael Joseph CalderonMing-Wen HuArchana Padmanabhan NairJoseph WeissChristopher S. FittingImran A. BhuttoSantosh Gopi Krishna GaddeNaveen Kumar NaikChaitra JaydevGerard A. LuttyJames T. HandaAshwath JayagopalJiang QianJosé-Alain SahelDhivyaa RajasundaramYuri SergeevJ. Samuel ZiglerSwaminathan SethuSimon WatkinsArkasubhra GhoshDebasish SinhaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Sayan Ghosh
Haitao Liu
Meysam Yazdankhah
Nadezda Stepicheva
Peng Shang
Tanuja Vaidya
Stacey Hose
Urvi Gupta
Michael Joseph Calderon
Ming-Wen Hu
Archana Padmanabhan Nair
Joseph Weiss
Christopher S. Fitting
Imran A. Bhutto
Santosh Gopi Krishna Gadde
Naveen Kumar Naik
Chaitra Jaydev
Gerard A. Lutty
James T. Handa
Ashwath Jayagopal
Jiang Qian
José-Alain Sahel
Dhivyaa Rajasundaram
Yuri Sergeev
J. Samuel Zigler
Swaminathan Sethu
Simon Watkins
Arkasubhra Ghosh
Debasish Sinha
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
description Ghosh et al. show that a lens protein βA1-crystallin inhibits PTP1B activity, regulating the metabolism of retinal astrocytes. They find that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in mice, suggesting the possibility that the interaction between βA1-PTP1B may be targeted for diabetic retinopathy.
format article
author Sayan Ghosh
Haitao Liu
Meysam Yazdankhah
Nadezda Stepicheva
Peng Shang
Tanuja Vaidya
Stacey Hose
Urvi Gupta
Michael Joseph Calderon
Ming-Wen Hu
Archana Padmanabhan Nair
Joseph Weiss
Christopher S. Fitting
Imran A. Bhutto
Santosh Gopi Krishna Gadde
Naveen Kumar Naik
Chaitra Jaydev
Gerard A. Lutty
James T. Handa
Ashwath Jayagopal
Jiang Qian
José-Alain Sahel
Dhivyaa Rajasundaram
Yuri Sergeev
J. Samuel Zigler
Swaminathan Sethu
Simon Watkins
Arkasubhra Ghosh
Debasish Sinha
author_facet Sayan Ghosh
Haitao Liu
Meysam Yazdankhah
Nadezda Stepicheva
Peng Shang
Tanuja Vaidya
Stacey Hose
Urvi Gupta
Michael Joseph Calderon
Ming-Wen Hu
Archana Padmanabhan Nair
Joseph Weiss
Christopher S. Fitting
Imran A. Bhutto
Santosh Gopi Krishna Gadde
Naveen Kumar Naik
Chaitra Jaydev
Gerard A. Lutty
James T. Handa
Ashwath Jayagopal
Jiang Qian
José-Alain Sahel
Dhivyaa Rajasundaram
Yuri Sergeev
J. Samuel Zigler
Swaminathan Sethu
Simon Watkins
Arkasubhra Ghosh
Debasish Sinha
author_sort Sayan Ghosh
title βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
title_short βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
title_full βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
title_fullStr βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
title_full_unstemmed βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
title_sort βa1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating ptp1b activity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/73f2d2042a5b442cb0991f9ae494dfe7
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