The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.

<h4>Background</h4>A year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological studies, through providing evidence of past infection, can aid understanding of the population dynamics of SARS-CoV-2 infection.<h4>Objectiv...

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Autores principales:	Natasha Marcella Vaselli, Daniel Hungerford, Ben Shenton, Arwa Khashkhusha, Nigel A Cunliffe, Neil French
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73f891d8697e40329f4f2112524ce743
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spelling	oai:doaj.org-article:73f891d8697e40329f4f2112524ce7432021-12-02T20:07:45ZThe seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.1932-620310.1371/journal.pone.0250541https://doaj.org/article/73f891d8697e40329f4f2112524ce7432021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0250541https://doaj.org/toc/1932-6203<h4>Background</h4>A year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological studies, through providing evidence of past infection, can aid understanding of the population dynamics of SARS-CoV-2 infection.<h4>Objectives</h4>This systematic review of SARS-CoV-2 seroprevalence studies in Europe was undertaken to inform public health strategies including vaccination, that aim to accelerate population immunity.<h4>Methods</h4>We searched the databases Web of Science, MEDLINE, EMBASE, SCOPUS, Cochrane Database of Systematic Reviews and grey literature sources for studies reporting seroprevalence of SARS-CoV-2 antibodies in Europe published between 01/12/2019-30/09/20. We provide a narrative synthesis of included studies. Studies were categorized into subgroups including healthcare workers (HCWs), community, outbreaks, pregnancy and children/school. Due to heterogeneity in other subgroups, we only performed a random effects meta-analysis of the seroprevalence amongst HCWs stratified by their country.<h4>Results</h4>115 studies were included spanning 17 European countries, that estimated the seroprevalence of SARS-CoV-2 from samples obtained between November 2019 -August 2020. A total of 54/115 studies included HCWs with a reported seroprevalence among HCWs ranging from 0.7% to 45.3%, which did not differ significantly by country. In community studies significant heterogeneity was reported in the seroprevalence between different age groups and the majority of studies reported there was no significant difference by gender.<h4>Conclusion</h4>This review demonstrates a wide heterogeneity in reported seroprevalence of SARS-CoV-2 antibodies between populations. Continued evaluation of seroprevalence is required to understand the impact of public health measures and inform interventions including vaccination programmes.Natasha Marcella VaselliDaniel HungerfordBen ShentonArwa KhashkhushaNigel A CunliffeNeil FrenchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0250541 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natasha Marcella Vaselli Daniel Hungerford Ben Shenton Arwa Khashkhusha Nigel A Cunliffe Neil French The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.
description	<h4>Background</h4>A year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological studies, through providing evidence of past infection, can aid understanding of the population dynamics of SARS-CoV-2 infection.<h4>Objectives</h4>This systematic review of SARS-CoV-2 seroprevalence studies in Europe was undertaken to inform public health strategies including vaccination, that aim to accelerate population immunity.<h4>Methods</h4>We searched the databases Web of Science, MEDLINE, EMBASE, SCOPUS, Cochrane Database of Systematic Reviews and grey literature sources for studies reporting seroprevalence of SARS-CoV-2 antibodies in Europe published between 01/12/2019-30/09/20. We provide a narrative synthesis of included studies. Studies were categorized into subgroups including healthcare workers (HCWs), community, outbreaks, pregnancy and children/school. Due to heterogeneity in other subgroups, we only performed a random effects meta-analysis of the seroprevalence amongst HCWs stratified by their country.<h4>Results</h4>115 studies were included spanning 17 European countries, that estimated the seroprevalence of SARS-CoV-2 from samples obtained between November 2019 -August 2020. A total of 54/115 studies included HCWs with a reported seroprevalence among HCWs ranging from 0.7% to 45.3%, which did not differ significantly by country. In community studies significant heterogeneity was reported in the seroprevalence between different age groups and the majority of studies reported there was no significant difference by gender.<h4>Conclusion</h4>This review demonstrates a wide heterogeneity in reported seroprevalence of SARS-CoV-2 antibodies between populations. Continued evaluation of seroprevalence is required to understand the impact of public health measures and inform interventions including vaccination programmes.
format	article
author	Natasha Marcella Vaselli Daniel Hungerford Ben Shenton Arwa Khashkhusha Nigel A Cunliffe Neil French
author_facet	Natasha Marcella Vaselli Daniel Hungerford Ben Shenton Arwa Khashkhusha Nigel A Cunliffe Neil French
author_sort	Natasha Marcella Vaselli
title	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.
title_short	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.
title_full	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.
title_fullStr	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.
title_full_unstemmed	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.
title_sort	seroprevalence of sars-cov-2 during the first wave in europe 2020: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/73f891d8697e40329f4f2112524ce743
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The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.

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