Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice
Masood A Khan,1 Ahmed N Aljarbou,2 Yousef H Aldebasi,1 Mohammed S Alorainy,3 Arif Khan1 1College of Applied Medical Sciences, 2College of Pharmacy, 3College of Medicine, Qassim University, Buraydah, Saudi Arabia Abstract: The present study aimed to assess the antitumor effect of glycosphingolipid-in...
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Dove Medical Press
2015
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oai:doaj.org-article:7402618cb7d042f2857a680e413db5992021-12-02T04:23:12ZCombination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice1178-2013https://doaj.org/article/7402618cb7d042f2857a680e413db5992015-10-01T00:00:00Zhttps://www.dovepress.com/combination-of-glycosphingosomes-and-liposomal-doxorubicin-shows-incre-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Masood A Khan,1 Ahmed N Aljarbou,2 Yousef H Aldebasi,1 Mohammed S Alorainy,3 Arif Khan1 1College of Applied Medical Sciences, 2College of Pharmacy, 3College of Medicine, Qassim University, Buraydah, Saudi Arabia Abstract: The present study aimed to assess the antitumor effect of glycosphingolipid-incorporated liposomes (glycosphingosomes) in combination with liposomal doxorubicin (Lip-Dox) in a mouse model of fibrosarcoma. Glycosphingosomes were prepared by incorporating glycosphingolipids isolated from Sphingomonas paucimobilis into the liposomes of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, cholesterol, and cardiolipin. Tumors were induced by administering dimethyl-α-benzanthracene, and tumor-bearing mice were treated with various formulations of Dox, including free Dox, Lip-Dox, or glycosphingosomes + Lip-Dox. Mice were observed for 90 days to monitor their survival and tumor size. Free Dox, but not Lip-Dox or a combination of glycosphingosomes and Lip-Dox, caused the substantial depletion of leukocytes and significantly increased the levels of lactate dehydrogenase and creatinine kinase in mice. Tumor-bearing mice treated with a combination of glycosphingosomes and Lip-Dox showed restricted tumor growth and increased survival when compared to those treated with free Dox or Lip-Dox. The results of the present study suggest that a combination of glycosphingosomes and Lip-Dox may prove to be very effective in the treatment of tumors. Keywords: glycosphingolipids, NKT cells, tumors, chemotherapyKhan MAAljarbou ANAldebasi YHAlorainy MSKhan ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 6331-6338 (2015) |
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DOAJ |
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DOAJ |
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EN |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Khan MA Aljarbou AN Aldebasi YH Alorainy MS Khan A Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice |
| description |
Masood A Khan,1 Ahmed N Aljarbou,2 Yousef H Aldebasi,1 Mohammed S Alorainy,3 Arif Khan1 1College of Applied Medical Sciences, 2College of Pharmacy, 3College of Medicine, Qassim University, Buraydah, Saudi Arabia Abstract: The present study aimed to assess the antitumor effect of glycosphingolipid-incorporated liposomes (glycosphingosomes) in combination with liposomal doxorubicin (Lip-Dox) in a mouse model of fibrosarcoma. Glycosphingosomes were prepared by incorporating glycosphingolipids isolated from Sphingomonas paucimobilis into the liposomes of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, cholesterol, and cardiolipin. Tumors were induced by administering dimethyl-α-benzanthracene, and tumor-bearing mice were treated with various formulations of Dox, including free Dox, Lip-Dox, or glycosphingosomes + Lip-Dox. Mice were observed for 90 days to monitor their survival and tumor size. Free Dox, but not Lip-Dox or a combination of glycosphingosomes and Lip-Dox, caused the substantial depletion of leukocytes and significantly increased the levels of lactate dehydrogenase and creatinine kinase in mice. Tumor-bearing mice treated with a combination of glycosphingosomes and Lip-Dox showed restricted tumor growth and increased survival when compared to those treated with free Dox or Lip-Dox. The results of the present study suggest that a combination of glycosphingosomes and Lip-Dox may prove to be very effective in the treatment of tumors. Keywords: glycosphingolipids, NKT cells, tumors, chemotherapy |
| format |
article |
| author |
Khan MA Aljarbou AN Aldebasi YH Alorainy MS Khan A |
| author_facet |
Khan MA Aljarbou AN Aldebasi YH Alorainy MS Khan A |
| author_sort |
Khan MA |
| title |
Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice |
| title_short |
Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice |
| title_full |
Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice |
| title_fullStr |
Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice |
| title_full_unstemmed |
Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice |
| title_sort |
combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/7402618cb7d042f2857a680e413db599 |
| work_keys_str_mv |
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