Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a

Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a

Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj...

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Autores principales: Dongchang Xiao, Xiaoning Liu, Min Zhang, Min Zou, Qinqin Deng, Dayu Sun, Xuting Bian, Yulong Cai, Yanan Guo, Shuting Liu, Shengguo Li, Evelyn Shiang, Hongyu Zhong, Lin Cheng, Haiwei Xu, Kangxin Jin, Mengqing Xiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/74045bf620e54535ac1ea7010f2ae0f9
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Sumario:Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj.

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