Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a
Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj...
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Nature Portfolio
2018
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oai:doaj.org-article:74045bf620e54535ac1ea7010f2ae0f92021-12-02T16:56:56ZDirect reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a10.1038/s41467-018-05209-12041-1723https://doaj.org/article/74045bf620e54535ac1ea7010f2ae0f92018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05209-1https://doaj.org/toc/2041-1723Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj.Dongchang XiaoXiaoning LiuMin ZhangMin ZouQinqin DengDayu SunXuting BianYulong CaiYanan GuoShuting LiuShengguo LiEvelyn ShiangHongyu ZhongLin ChengHaiwei XuKangxin JinMengqing XiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dongchang Xiao Xiaoning Liu Min Zhang Min Zou Qinqin Deng Dayu Sun Xuting Bian Yulong Cai Yanan Guo Shuting Liu Shengguo Li Evelyn Shiang Hongyu Zhong Lin Cheng Haiwei Xu Kangxin Jin Mengqing Xiang Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a |
| description |
Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj. |
| format |
article |
| author |
Dongchang Xiao Xiaoning Liu Min Zhang Min Zou Qinqin Deng Dayu Sun Xuting Bian Yulong Cai Yanan Guo Shuting Liu Shengguo Li Evelyn Shiang Hongyu Zhong Lin Cheng Haiwei Xu Kangxin Jin Mengqing Xiang |
| author_facet |
Dongchang Xiao Xiaoning Liu Min Zhang Min Zou Qinqin Deng Dayu Sun Xuting Bian Yulong Cai Yanan Guo Shuting Liu Shengguo Li Evelyn Shiang Hongyu Zhong Lin Cheng Haiwei Xu Kangxin Jin Mengqing Xiang |
| author_sort |
Dongchang Xiao |
| title |
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a |
| title_short |
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a |
| title_full |
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a |
| title_fullStr |
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a |
| title_full_unstemmed |
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a |
| title_sort |
direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor ptf1a |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/74045bf620e54535ac1ea7010f2ae0f9 |
| work_keys_str_mv |
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1718382688100941824 |