Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

Waleed M Alghamdi, Saif H Alrasheed, Vishakh Nair, Muhammed S Alluwimi Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi ArabiaCorrespondence: Saif H AlrasheedQassim Unversity, P.O. Box 1162, Buraydah, Saudi ArabiaTel +966505201475Fax +966-16-3800050Ema...

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Auteurs principaux:	Alghamdi WM, Alrasheed SH, Nair V, Alluwimi MS
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2021
Sujets:	cycloplegic anterior chamber angle anterior chamber volume depth central corneal thickness Ophthalmology RE1-994
Accès en ligne:	https://doaj.org/article/740518946c14467bb0cebaa14775b220
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spelling	oai:doaj.org-article:740518946c14467bb0cebaa14775b2202021-12-02T14:32:47ZEffects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)1177-5483https://doaj.org/article/740518946c14467bb0cebaa14775b2202021-03-01T00:00:00Zhttps://www.dovepress.com/effects-of-cyclopentolate-hydrochloride-dosage-on-anterior-segment-par-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Waleed M Alghamdi, Saif H Alrasheed, Vishakh Nair, Muhammed S Alluwimi Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi ArabiaCorrespondence: Saif H AlrasheedQassim Unversity, P.O. Box 1162, Buraydah, Saudi ArabiaTel +966505201475Fax +966-16-3800050Email s.rasheed@qu.edu.saPurpose: To assess the effects of 0.5% and 1% cyclopentolate on the main parameters of the anterior segment (central corneal thickness (CCT), anterior chamber angle (ACA), depth (ACD) and volume (ACV)) in low/moderate myopia and hyperopia along with the effect on IOP.Patients and Methods: Both eyes of 30 subjects (15 myopic and 15 hyperopic) with mean age±standard deviation of 21.4± 3.6 years were enrolled. Each participant was administered two drops of cyclopentolate 1% in the right eye and two drops of cyclopentolate 0.5% in the left eye, 15 minutes apart. All participants underwent intraocular pressure (IOP) measurement using noncontact tonometry, and anterior chamber parameter measurement using Pentacam.Results: Following the use of 0.5% and 1% cyclopentolate among the hyperopic group, there was a statistically significant increase in ACD for 1% (pre 2.762± 0.28 mm and post 2.89± 0.25 mm) and 0.5% (pre 2.71± 0.28 and post 2.86± 0.27 mm) and ACV for 1% (pre 141.40± 20.59 mm3 and post 154.35± 19.69 mm3) and 0.5% (pre 137.40± 20.48 mm3 and post 152.93± 20.50 mm3). In contrast, ACA decreased with both doses 1% and 0.5%, but was not statistically significant (p for both > 0.05%). With 0.5% and 1% cyclopentolate among the myopia group, there was a signiﬁcant increase in ACD following cyclopentolate 1% (pre 3.18± 0.22 mm and post 3.25± 0.21 mm) and 0.5% (pre 3.200± 0.22 mm and post 3.26± 0.05 mm), p˂0.05. The ACV was significantly increased following 1% cyclopentolate, p˂0.001. The ACA showed a statistically signiﬁcant decrease following cyclopentolate 1%, P=0.01, but not a significant decrease after cyclopentolate 0.5%, P=0.170. There was a significant increase in the IOP after 1%, p˂0.001, while a decrease with 0.5%, p=0.008.Conclusion: A topical dosage of cyclopentolate 1% showed significant changes in ACA and ACV among the hyperopia and myopic groups compared to 0.5%. Therefore, it is important to consider the use of a 0.5% cyclopentolate dosage to minimize changes to anterior chamber parameters.Keywords: cycloplegic, anterior chamber angle, anterior chamber volume depth, central corneal thicknessAlghamdi WMAlrasheed SHNair VAlluwimi MSDove Medical Pressarticlecycloplegicanterior chamber angleanterior chamber volume depthcentral corneal thicknessOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 891-898 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cycloplegic anterior chamber angle anterior chamber volume depth central corneal thickness Ophthalmology RE1-994
spellingShingle	cycloplegic anterior chamber angle anterior chamber volume depth central corneal thickness Ophthalmology RE1-994 Alghamdi WM Alrasheed SH Nair V Alluwimi MS Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)
description	Waleed M Alghamdi, Saif H Alrasheed, Vishakh Nair, Muhammed S Alluwimi Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi ArabiaCorrespondence: Saif H AlrasheedQassim Unversity, P.O. Box 1162, Buraydah, Saudi ArabiaTel +966505201475Fax +966-16-3800050Email s.rasheed@qu.edu.saPurpose: To assess the effects of 0.5% and 1% cyclopentolate on the main parameters of the anterior segment (central corneal thickness (CCT), anterior chamber angle (ACA), depth (ACD) and volume (ACV)) in low/moderate myopia and hyperopia along with the effect on IOP.Patients and Methods: Both eyes of 30 subjects (15 myopic and 15 hyperopic) with mean age±standard deviation of 21.4± 3.6 years were enrolled. Each participant was administered two drops of cyclopentolate 1% in the right eye and two drops of cyclopentolate 0.5% in the left eye, 15 minutes apart. All participants underwent intraocular pressure (IOP) measurement using noncontact tonometry, and anterior chamber parameter measurement using Pentacam.Results: Following the use of 0.5% and 1% cyclopentolate among the hyperopic group, there was a statistically significant increase in ACD for 1% (pre 2.762± 0.28 mm and post 2.89± 0.25 mm) and 0.5% (pre 2.71± 0.28 and post 2.86± 0.27 mm) and ACV for 1% (pre 141.40± 20.59 mm3 and post 154.35± 19.69 mm3) and 0.5% (pre 137.40± 20.48 mm3 and post 152.93± 20.50 mm3). In contrast, ACA decreased with both doses 1% and 0.5%, but was not statistically significant (p for both > 0.05%). With 0.5% and 1% cyclopentolate among the myopia group, there was a signiﬁcant increase in ACD following cyclopentolate 1% (pre 3.18± 0.22 mm and post 3.25± 0.21 mm) and 0.5% (pre 3.200± 0.22 mm and post 3.26± 0.05 mm), p˂0.05. The ACV was significantly increased following 1% cyclopentolate, p˂0.001. The ACA showed a statistically signiﬁcant decrease following cyclopentolate 1%, P=0.01, but not a significant decrease after cyclopentolate 0.5%, P=0.170. There was a significant increase in the IOP after 1%, p˂0.001, while a decrease with 0.5%, p=0.008.Conclusion: A topical dosage of cyclopentolate 1% showed significant changes in ACA and ACV among the hyperopia and myopic groups compared to 0.5%. Therefore, it is important to consider the use of a 0.5% cyclopentolate dosage to minimize changes to anterior chamber parameters.Keywords: cycloplegic, anterior chamber angle, anterior chamber volume depth, central corneal thickness
format	article
author	Alghamdi WM Alrasheed SH Nair V Alluwimi MS
author_facet	Alghamdi WM Alrasheed SH Nair V Alluwimi MS
author_sort	Alghamdi WM
title	Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)
title_short	Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)
title_full	Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)
title_fullStr	Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)
title_full_unstemmed	Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)
title_sort	effects of cyclopentolate hydrochloride dosage on anterior segment parameters in young adults (measured with pentacam)
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/740518946c14467bb0cebaa14775b220
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Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

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