«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK

«Candidatus Midichloria mitochondrii» is the sheep tick Ixodes ricinus endosymbiont. This unique bacteria can occupy and persist within the mitochondria of animals. I. ricinus is an important vector of human pathogens in natural focal of infections. «Candidatus M. mitochondrii» found in the intermem...

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Autor principal:	S. N. Shpynov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2017
Materias:	«candidatus midichloria mitochondrii» endosymbiont malos (midichloria and like organisms) order rickettsiales ticks ixodes ricinus mitochondria Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/7405795d3c2644bda395116ef6112b18
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spelling	oai:doaj.org-article:7405795d3c2644bda395116ef6112b182021-11-22T07:09:48Z«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK2220-76192313-739810.15789/2220-7619-2016-4-315-324https://doaj.org/article/7405795d3c2644bda395116ef6112b182017-01-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/443https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398«Candidatus Midichloria mitochondrii» is the sheep tick Ixodes ricinus endosymbiont. This unique bacteria can occupy and persist within the mitochondria of animals. I. ricinus is an important vector of human pathogens in natural focal of infections. «Candidatus M. mitochondrii» found in the intermembrane space of mitochondria and in the cytoplasm of ovarian cells in 100% females of I. ricinus. The bacteria contain flagella in the salivary glands of ticks. «Candidatus M. mitochondrii» has two groups of unique genes for the members of the order Rickettsiales (cbb3 cytochrome oxidase and flagellin), which allows it to play an important role in embryogenesis of the I. ricinus ticks and cause seroconversion in 58% of patients after ticks bloodsucking. This bacterium formed MALOs group (midichloria and like organisms) with genetically closely related organisms which demonstrated a association with a wide range of host from arthropods to ciliates, amoebae, sponges, fish and various animals and humans. Now there is no data about replication the «Candidatus M. mitochondrii» in humans and pathogenicity of this microorganism. Although a high percentage of seropositive samples obtained from patients after bloodsucking of I. ricinus in anamnesis, this bacterium cannot yet be regarded as responsible for the pathology as known human pathogenic from order Rickettsi-ales (Rickettsia, Anaplasma and Ehrlichia spp.). Needed to reconsider the attitude to an immune response to the saliva of I. ricinus, taking into account the potential impact of «Candidatus M. mitochondrii». It is considered highly possible role of this bacterium in the immune response and immunomodulation in humans with bloodsucking of I. ricinus in anamnesis. DNA of «Candidatus M. mitochondrii» was the first time detected in I. ricinus ticks from European part of Russia.S. N. ShpynovSankt-Peterburg : NIIÈM imeni Pasteraarticle«candidatus midichloria mitochondrii»endosymbiontmalos (midichloria and like organisms)order rickettsialesticksixodes ricinusmitochondriaInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 4, Pp 315-324 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	«candidatus midichloria mitochondrii» endosymbiont malos (midichloria and like organisms) order rickettsiales ticks ixodes ricinus mitochondria Infectious and parasitic diseases RC109-216
spellingShingle	«candidatus midichloria mitochondrii» endosymbiont malos (midichloria and like organisms) order rickettsiales ticks ixodes ricinus mitochondria Infectious and parasitic diseases RC109-216 S. N. Shpynov «CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK
description	«Candidatus Midichloria mitochondrii» is the sheep tick Ixodes ricinus endosymbiont. This unique bacteria can occupy and persist within the mitochondria of animals. I. ricinus is an important vector of human pathogens in natural focal of infections. «Candidatus M. mitochondrii» found in the intermembrane space of mitochondria and in the cytoplasm of ovarian cells in 100% females of I. ricinus. The bacteria contain flagella in the salivary glands of ticks. «Candidatus M. mitochondrii» has two groups of unique genes for the members of the order Rickettsiales (cbb3 cytochrome oxidase and flagellin), which allows it to play an important role in embryogenesis of the I. ricinus ticks and cause seroconversion in 58% of patients after ticks bloodsucking. This bacterium formed MALOs group (midichloria and like organisms) with genetically closely related organisms which demonstrated a association with a wide range of host from arthropods to ciliates, amoebae, sponges, fish and various animals and humans. Now there is no data about replication the «Candidatus M. mitochondrii» in humans and pathogenicity of this microorganism. Although a high percentage of seropositive samples obtained from patients after bloodsucking of I. ricinus in anamnesis, this bacterium cannot yet be regarded as responsible for the pathology as known human pathogenic from order Rickettsi-ales (Rickettsia, Anaplasma and Ehrlichia spp.). Needed to reconsider the attitude to an immune response to the saliva of I. ricinus, taking into account the potential impact of «Candidatus M. mitochondrii». It is considered highly possible role of this bacterium in the immune response and immunomodulation in humans with bloodsucking of I. ricinus in anamnesis. DNA of «Candidatus M. mitochondrii» was the first time detected in I. ricinus ticks from European part of Russia.
format	article
author	S. N. Shpynov
author_facet	S. N. Shpynov
author_sort	S. N. Shpynov
title	«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK
title_short	«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK
title_full	«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK
title_fullStr	«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK
title_full_unstemmed	«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK
title_sort	«candidatus midichloria mitochondrii»: a new member of order rickettsiales, endosymbiont of ixodes ricinus tick
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2017
url	https://doaj.org/article/7405795d3c2644bda395116ef6112b18
work_keys_str_mv	AT snshpynov candidatusmidichloriamitochondriianewmemberoforderrickettsialesendosymbiontofixodesricinustick
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«CANDIDATUS MIDICHLORIA MITOCHONDRII»: A NEW MEMBER OF ORDER RICKETTSIALES, ENDOSYMBIONT OF IXODES RICINUS TICK

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