Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.

In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous substrates. The latter include a recently identified regulatory phosphorylation of the GM-CSF/IL-3 βc receptor contributing to survival of acut...

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Autores principales: Christina M Buchanan, James M J Dickson, Woo-Jeong Lee, Mark A Guthridge, Jackie D Kendall, Peter R Shepherd
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/74058d667bd6498ab44f3854baf56a0d
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