Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults

Background: Whether multiple nutritional deficiencies have a synergic effect on mobility loss remains unknown. This study aims to evaluate associations between multi-nutritional deficits and physical performance evolution among community-dwelling older adults.Methods: We included 386 participants fr...

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Autores principales:	Wan-Hsuan Lu, Kelly Virecoulon Giudici, Yves Rolland, Sophie Guyonnet, Jean-François Mangin, Bruno Vellas, Philipe de Souto Barreto
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	vitamin D homocysteine omega-3 fatty acids physical performance inflammation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/7408044edb12415dacabfc66487088db
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spelling	oai:doaj.org-article:7408044edb12415dacabfc66487088db2021-11-11T10:25:03ZAssociations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults2296-861X10.3389/fnut.2021.771470https://doaj.org/article/7408044edb12415dacabfc66487088db2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.771470/fullhttps://doaj.org/toc/2296-861XBackground: Whether multiple nutritional deficiencies have a synergic effect on mobility loss remains unknown. This study aims to evaluate associations between multi-nutritional deficits and physical performance evolution among community-dwelling older adults.Methods: We included 386 participants from the Multidomain Alzheimer Preventive Trial (MAPT) (75.6 ± 4.5 years) not receiving omega-3 polyunsaturated fatty acid (PUFA) supplementation and who had available data on nutritional deficits. Baseline nutritional deficits were defined as plasma 25 hydroxyvitamin D <20 ng/ml, plasma homocysteine >14 μmol/L, or erythrocyte omega-3 PUFA index ≤ 4.87% (lower quartile). The Short Physical Performance Battery (SPPB), gait speed, and chair rise time were used to assess physical performance at baseline and after 6, 12, 24, 36, 48, and 60 months. We explored if nutrition-physical performance associations varied according to the presence of low-grade inflammation (LGI) and brain imaging indicators.Results: Within-group comparisons showed that physical function (decreased SPPB and gait speed, increased chair rise time) worsened over time, particularly in participants with ≥2 nutritional deficits; however, no between-group differences were observed when individuals without deficit and those with either 1 or ≥2 deficits were compared. Our exploratory analysis on nutritional deficit-LGI interactions showed that, among people with ≥2 deficits, chair rise time was increased over time in participants with LGI (adjusted mean difference: 3.47; 95% CI: 1.03, 5.91; p = 0.017), compared with individuals with no LGI.Conclusions: Accumulated deficits on vitamin D, homocysteine, and omega-3 PUFA were not associated with physical performance evolution in older adults, but they determined declined chair rise performance in subjects with low-grade inflammation.Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT00672685], identifier [NCT00672685].Wan-Hsuan LuWan-Hsuan LuKelly Virecoulon GiudiciYves RollandYves RollandSophie GuyonnetSophie GuyonnetJean-François ManginJean-François ManginBruno VellasBruno VellasPhilipe de Souto BarretoPhilipe de Souto BarretoFrontiers Media S.A.articlevitamin Dhomocysteineomega-3 fatty acidsphysical performanceinflammationNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D homocysteine omega-3 fatty acids physical performance inflammation Nutrition. Foods and food supply TX341-641
spellingShingle	vitamin D homocysteine omega-3 fatty acids physical performance inflammation Nutrition. Foods and food supply TX341-641 Wan-Hsuan Lu Wan-Hsuan Lu Kelly Virecoulon Giudici Yves Rolland Yves Rolland Sophie Guyonnet Sophie Guyonnet Jean-François Mangin Jean-François Mangin Bruno Vellas Bruno Vellas Philipe de Souto Barreto Philipe de Souto Barreto Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults
description	Background: Whether multiple nutritional deficiencies have a synergic effect on mobility loss remains unknown. This study aims to evaluate associations between multi-nutritional deficits and physical performance evolution among community-dwelling older adults.Methods: We included 386 participants from the Multidomain Alzheimer Preventive Trial (MAPT) (75.6 ± 4.5 years) not receiving omega-3 polyunsaturated fatty acid (PUFA) supplementation and who had available data on nutritional deficits. Baseline nutritional deficits were defined as plasma 25 hydroxyvitamin D <20 ng/ml, plasma homocysteine >14 μmol/L, or erythrocyte omega-3 PUFA index ≤ 4.87% (lower quartile). The Short Physical Performance Battery (SPPB), gait speed, and chair rise time were used to assess physical performance at baseline and after 6, 12, 24, 36, 48, and 60 months. We explored if nutrition-physical performance associations varied according to the presence of low-grade inflammation (LGI) and brain imaging indicators.Results: Within-group comparisons showed that physical function (decreased SPPB and gait speed, increased chair rise time) worsened over time, particularly in participants with ≥2 nutritional deficits; however, no between-group differences were observed when individuals without deficit and those with either 1 or ≥2 deficits were compared. Our exploratory analysis on nutritional deficit-LGI interactions showed that, among people with ≥2 deficits, chair rise time was increased over time in participants with LGI (adjusted mean difference: 3.47; 95% CI: 1.03, 5.91; p = 0.017), compared with individuals with no LGI.Conclusions: Accumulated deficits on vitamin D, homocysteine, and omega-3 PUFA were not associated with physical performance evolution in older adults, but they determined declined chair rise performance in subjects with low-grade inflammation.Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT00672685], identifier [NCT00672685].
format	article
author	Wan-Hsuan Lu Wan-Hsuan Lu Kelly Virecoulon Giudici Yves Rolland Yves Rolland Sophie Guyonnet Sophie Guyonnet Jean-François Mangin Jean-François Mangin Bruno Vellas Bruno Vellas Philipe de Souto Barreto Philipe de Souto Barreto
author_facet	Wan-Hsuan Lu Wan-Hsuan Lu Kelly Virecoulon Giudici Yves Rolland Yves Rolland Sophie Guyonnet Sophie Guyonnet Jean-François Mangin Jean-François Mangin Bruno Vellas Bruno Vellas Philipe de Souto Barreto Philipe de Souto Barreto
author_sort	Wan-Hsuan Lu
title	Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults
title_short	Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults
title_full	Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults
title_fullStr	Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults
title_full_unstemmed	Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults
title_sort	associations between nutritional deficits and physical performance in community-dwelling older adults
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7408044edb12415dacabfc66487088db
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Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults

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