Association between paternal age and singleton birthweight in frozen embryo transfer cycles

Plain English summary Currently, many couples delay childbearing until after the age of 40. The natural decline of fertility of elderly couples forces them to utilize assisted reproductive technology. Although males continuously produce sperm throughout their entire life, their sperm quality decreas...

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Autores principales:	Zhexin Ni, Demeng Xia, Shuai Sun, Danying Zhang, Yanping Kuang, Chaoqin Yu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Assisted reproductive technology Frozen embryo transfer Vitrification Paternal age Birthweight Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/7408d73940fc43e3a43839151d7688c7
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spelling	oai:doaj.org-article:7408d73940fc43e3a43839151d7688c72021-11-08T11:03:19ZAssociation between paternal age and singleton birthweight in frozen embryo transfer cycles10.1186/s12978-021-01250-41742-4755https://doaj.org/article/7408d73940fc43e3a43839151d7688c72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12978-021-01250-4https://doaj.org/toc/1742-4755Plain English summary Currently, many couples delay childbearing until after the age of 40. The natural decline of fertility of elderly couples forces them to utilize assisted reproductive technology. Although males continuously produce sperm throughout their entire life, their sperm quality decreases, changes occur in reproductive hormones, the incidence of de novo mutations increases, and negative behavioral choices could cause a decline in males’ fertility potential after the age of 40. Due to their age women may also face fertility issues that have an impact on pregnancy and childbirth. This study only included couples who had successfully given birth in frozen embryo transfer cycles. Considering that birthweight is an important indicator of neonatal health, we explored the association between paternal age and singleton birthweight. Our study found that paternal age is not associated with mean birthweight and gestational age- and gender-adjusted birthweight (Z-scores) of singletons in FET cycles, showing chances of successful pregnancy in couples over 40 years of age have improved.Zhexin NiDemeng XiaShuai SunDanying ZhangYanping KuangChaoqin YuBMCarticleAssisted reproductive technologyFrozen embryo transferVitrificationPaternal ageBirthweightGynecology and obstetricsRG1-991ENReproductive Health, Vol 18, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Assisted reproductive technology Frozen embryo transfer Vitrification Paternal age Birthweight Gynecology and obstetrics RG1-991
spellingShingle	Assisted reproductive technology Frozen embryo transfer Vitrification Paternal age Birthweight Gynecology and obstetrics RG1-991 Zhexin Ni Demeng Xia Shuai Sun Danying Zhang Yanping Kuang Chaoqin Yu Association between paternal age and singleton birthweight in frozen embryo transfer cycles
description	Plain English summary Currently, many couples delay childbearing until after the age of 40. The natural decline of fertility of elderly couples forces them to utilize assisted reproductive technology. Although males continuously produce sperm throughout their entire life, their sperm quality decreases, changes occur in reproductive hormones, the incidence of de novo mutations increases, and negative behavioral choices could cause a decline in males’ fertility potential after the age of 40. Due to their age women may also face fertility issues that have an impact on pregnancy and childbirth. This study only included couples who had successfully given birth in frozen embryo transfer cycles. Considering that birthweight is an important indicator of neonatal health, we explored the association between paternal age and singleton birthweight. Our study found that paternal age is not associated with mean birthweight and gestational age- and gender-adjusted birthweight (Z-scores) of singletons in FET cycles, showing chances of successful pregnancy in couples over 40 years of age have improved.
format	article
author	Zhexin Ni Demeng Xia Shuai Sun Danying Zhang Yanping Kuang Chaoqin Yu
author_facet	Zhexin Ni Demeng Xia Shuai Sun Danying Zhang Yanping Kuang Chaoqin Yu
author_sort	Zhexin Ni
title	Association between paternal age and singleton birthweight in frozen embryo transfer cycles
title_short	Association between paternal age and singleton birthweight in frozen embryo transfer cycles
title_full	Association between paternal age and singleton birthweight in frozen embryo transfer cycles
title_fullStr	Association between paternal age and singleton birthweight in frozen embryo transfer cycles
title_full_unstemmed	Association between paternal age and singleton birthweight in frozen embryo transfer cycles
title_sort	association between paternal age and singleton birthweight in frozen embryo transfer cycles
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7408d73940fc43e3a43839151d7688c7
work_keys_str_mv	AT zhexinni associationbetweenpaternalageandsingletonbirthweightinfrozenembryotransfercycles AT demengxia associationbetweenpaternalageandsingletonbirthweightinfrozenembryotransfercycles AT shuaisun associationbetweenpaternalageandsingletonbirthweightinfrozenembryotransfercycles AT danyingzhang associationbetweenpaternalageandsingletonbirthweightinfrozenembryotransfercycles AT yanpingkuang associationbetweenpaternalageandsingletonbirthweightinfrozenembryotransfercycles AT chaoqinyu associationbetweenpaternalageandsingletonbirthweightinfrozenembryotransfercycles
_version_	1718442437736660992

Association between paternal age and singleton birthweight in frozen embryo transfer cycles

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