Factors associated with inflamm-aging in institutionalized older people

Abstract The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with thi...

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Autores principales:	Leônidas de Oliveira Neto, Vagner Deuel de O. Tavares, Pedro Moraes Dutra Agrícola, Larissa Praça de Oliveira, Márcia Cristina Sales, Karine Cavalcanti Maurício de Sena-Evangelista, Igor Conterato Gomes, Nicole Leite Galvão-Coelho, Lúcia Fátima Campos Pedrosa, Kenio Costa Lima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/740c3a1f80e540708d69f856437ade95
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spelling	oai:doaj.org-article:740c3a1f80e540708d69f856437ade952021-12-02T18:02:31ZFactors associated with inflamm-aging in institutionalized older people10.1038/s41598-021-97225-32045-2322https://doaj.org/article/740c3a1f80e540708d69f856437ade952021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97225-3https://doaj.org/toc/2045-2322Abstract The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80 years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80 years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.Leônidas de Oliveira NetoVagner Deuel de O. TavaresPedro Moraes Dutra AgrícolaLarissa Praça de OliveiraMárcia Cristina SalesKarine Cavalcanti Maurício de Sena-EvangelistaIgor Conterato GomesNicole Leite Galvão-CoelhoLúcia Fátima Campos PedrosaKenio Costa LimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leônidas de Oliveira Neto Vagner Deuel de O. Tavares Pedro Moraes Dutra Agrícola Larissa Praça de Oliveira Márcia Cristina Sales Karine Cavalcanti Maurício de Sena-Evangelista Igor Conterato Gomes Nicole Leite Galvão-Coelho Lúcia Fátima Campos Pedrosa Kenio Costa Lima Factors associated with inflamm-aging in institutionalized older people
description	Abstract The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80 years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80 years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.
format	article
author	Leônidas de Oliveira Neto Vagner Deuel de O. Tavares Pedro Moraes Dutra Agrícola Larissa Praça de Oliveira Márcia Cristina Sales Karine Cavalcanti Maurício de Sena-Evangelista Igor Conterato Gomes Nicole Leite Galvão-Coelho Lúcia Fátima Campos Pedrosa Kenio Costa Lima
author_facet	Leônidas de Oliveira Neto Vagner Deuel de O. Tavares Pedro Moraes Dutra Agrícola Larissa Praça de Oliveira Márcia Cristina Sales Karine Cavalcanti Maurício de Sena-Evangelista Igor Conterato Gomes Nicole Leite Galvão-Coelho Lúcia Fátima Campos Pedrosa Kenio Costa Lima
author_sort	Leônidas de Oliveira Neto
title	Factors associated with inflamm-aging in institutionalized older people
title_short	Factors associated with inflamm-aging in institutionalized older people
title_full	Factors associated with inflamm-aging in institutionalized older people
title_fullStr	Factors associated with inflamm-aging in institutionalized older people
title_full_unstemmed	Factors associated with inflamm-aging in institutionalized older people
title_sort	factors associated with inflamm-aging in institutionalized older people
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/740c3a1f80e540708d69f856437ade95
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Factors associated with inflamm-aging in institutionalized older people

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