Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection

Victoria WY Wong, Carmen KM Chan, Dexter YL Leung, Timothy YY LaiDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong, People&#39;s Republic of ChinaBackground: The purpose of this study was to assess the efficacy of oral val...

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Autores principales:	Wong VW, Chan CK, Leung DY, Lai TY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/740e22bfe7e54495b87f53ffa7894144
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spelling	oai:doaj.org-article:740e22bfe7e54495b87f53ffa78941442021-12-02T07:01:48ZLong-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection1177-54671177-5483https://doaj.org/article/740e22bfe7e54495b87f53ffa78941442012-04-01T00:00:00Zhttp://www.dovepress.com/long-term-results-of-oral-valganciclovir-for-treatment-of-anterior-seg-a9703https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Victoria WY Wong, Carmen KM Chan, Dexter YL Leung, Timothy YY LaiDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong, People&#39;s Republic of ChinaBackground: The purpose of this study was to assess the efficacy of oral valganciclovir in the treatment of anterior segment inflammation caused by cytomegalovirus (CMV) infection.Methods: Consecutive patients with anterior segment inflammation due to CMV causing anterior uveitis or corneal endotheliitis treated with oral valganciclovir were reviewed. Diagnosis of CMV infection was confirmed by polymerase chain reaction of the aqueous aspirate prior to commencement of oral valganciclovir. All patients were treated with an oral loading dose of 900 mg valganciclovir twice daily for at least 2 weeks, followed by an additional 450 mg valganciclovir twice-daily maintenance therapy. Changes in visual acuity, intraocular pressure (IOP), use of antiglaucomatous eye drops, and recurrence were analyzed.Results: Thirteen eyes of 11 patients were followed for a mean of 17.2 months. Two patients had bilateral corneal endotheliitis. All eyes had absence of anterior segment inflammation within 3 weeks after treatment. Following treatment, the mean logMAR visual acuity improved significantly from 0.58 at baseline to 0.37 at the last follow-up (P = 0.048). The mean IOP and number of antiglaucomatous eye drops also decreased significantly (P = 0.021 and P = 0.004, respectively). Five (38.5%) eyes had recurrence of anterior uveitis after valganciclovir was stopped and required retreatment with oral valganciclovir.Conclusion: Oral valganciclovir appeared to be effective in controlling CMV anterior uveitis, resulting in visual improvement and IOP reduction following control of inflammation. However, despite the initial clinical response in all cases, recurrence after cessation of oral valganciclovir could occur.Keywords: cytomegalovirus infection, inflammation, anterior uveitis, endotheliitis, ocular hypertension, antiviral, valganciclovirWong VWChan CKLeung DYLai TYDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 595-600 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Wong VW Chan CK Leung DY Lai TY Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
description	Victoria WY Wong, Carmen KM Chan, Dexter YL Leung, Timothy YY LaiDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong, People&#39;s Republic of ChinaBackground: The purpose of this study was to assess the efficacy of oral valganciclovir in the treatment of anterior segment inflammation caused by cytomegalovirus (CMV) infection.Methods: Consecutive patients with anterior segment inflammation due to CMV causing anterior uveitis or corneal endotheliitis treated with oral valganciclovir were reviewed. Diagnosis of CMV infection was confirmed by polymerase chain reaction of the aqueous aspirate prior to commencement of oral valganciclovir. All patients were treated with an oral loading dose of 900 mg valganciclovir twice daily for at least 2 weeks, followed by an additional 450 mg valganciclovir twice-daily maintenance therapy. Changes in visual acuity, intraocular pressure (IOP), use of antiglaucomatous eye drops, and recurrence were analyzed.Results: Thirteen eyes of 11 patients were followed for a mean of 17.2 months. Two patients had bilateral corneal endotheliitis. All eyes had absence of anterior segment inflammation within 3 weeks after treatment. Following treatment, the mean logMAR visual acuity improved significantly from 0.58 at baseline to 0.37 at the last follow-up (P = 0.048). The mean IOP and number of antiglaucomatous eye drops also decreased significantly (P = 0.021 and P = 0.004, respectively). Five (38.5%) eyes had recurrence of anterior uveitis after valganciclovir was stopped and required retreatment with oral valganciclovir.Conclusion: Oral valganciclovir appeared to be effective in controlling CMV anterior uveitis, resulting in visual improvement and IOP reduction following control of inflammation. However, despite the initial clinical response in all cases, recurrence after cessation of oral valganciclovir could occur.Keywords: cytomegalovirus infection, inflammation, anterior uveitis, endotheliitis, ocular hypertension, antiviral, valganciclovir
format	article
author	Wong VW Chan CK Leung DY Lai TY
author_facet	Wong VW Chan CK Leung DY Lai TY
author_sort	Wong VW
title	Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
title_short	Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
title_full	Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
title_fullStr	Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
title_full_unstemmed	Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
title_sort	long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/740e22bfe7e54495b87f53ffa7894144
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Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection

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