The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis

The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis

The DIS3L2 exonuclease degrades aberrant 7SL RNAs tagged by an oligouridine 3′-tail. Here the authors analyze DIS3L2 knockout mouse embryonic stem cells and suggest that DIS3L2-mediated quality control of 7SL RNA is important for ER-mediated translation and calcium ion homeostasis.

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Autores principales: Mehdi Pirouz, Chih-Hao Wang, Qi Liu, Aref G. Ebrahimi, Farnaz Shamsi, Yu-Hua Tseng, Richard I. Gregory
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/740eb5c2c0f64fa4b67534891edef46a
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spelling oai:doaj.org-article:740eb5c2c0f64fa4b67534891edef46a2021-12-02T16:52:57ZThe Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis10.1038/s41467-020-16418-y2041-1723https://doaj.org/article/740eb5c2c0f64fa4b67534891edef46a2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16418-yhttps://doaj.org/toc/2041-1723The DIS3L2 exonuclease degrades aberrant 7SL RNAs tagged by an oligouridine 3′-tail. Here the authors analyze DIS3L2 knockout mouse embryonic stem cells and suggest that DIS3L2-mediated quality control of 7SL RNA is important for ER-mediated translation and calcium ion homeostasis.Mehdi PirouzChih-Hao WangQi LiuAref G. EbrahimiFarnaz ShamsiYu-Hua TsengRichard I. GregoryNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mehdi Pirouz
Chih-Hao Wang
Qi Liu
Aref G. Ebrahimi
Farnaz Shamsi
Yu-Hua Tseng
Richard I. Gregory
The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis
description The DIS3L2 exonuclease degrades aberrant 7SL RNAs tagged by an oligouridine 3′-tail. Here the authors analyze DIS3L2 knockout mouse embryonic stem cells and suggest that DIS3L2-mediated quality control of 7SL RNA is important for ER-mediated translation and calcium ion homeostasis.
format article
author Mehdi Pirouz
Chih-Hao Wang
Qi Liu
Aref G. Ebrahimi
Farnaz Shamsi
Yu-Hua Tseng
Richard I. Gregory
author_facet Mehdi Pirouz
Chih-Hao Wang
Qi Liu
Aref G. Ebrahimi
Farnaz Shamsi
Yu-Hua Tseng
Richard I. Gregory
author_sort Mehdi Pirouz
title The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis
title_short The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis
title_full The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis
title_fullStr The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis
title_full_unstemmed The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis
title_sort perlman syndrome dis3l2 exoribonuclease safeguards endoplasmic reticulum-targeted mrna translation and calcium ion homeostasis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/740eb5c2c0f64fa4b67534891edef46a
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