Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos

Abstract Burkholderia pseudomallei, causative agent of the often fatal disease melioidosis, dwells in tropical soils and has been found in freshwater bodies. To investigate whether rivers are potential habitats or carriers for B. pseudomallei and to assess its geographical distribution in Laos, we s...

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Autores principales:	Rosalie E. Zimmermann, Olivier Ribolzi, Alain Pierret, Sayaphet Rattanavong, Matthew T. Robinson, Paul N. Newton, Viengmon Davong, Yves Auda, Jakob Zopfi, David A. B. Dance
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7416126acc8c476fba44f7d77dd95a75
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spelling	oai:doaj.org-article:7416126acc8c476fba44f7d77dd95a752021-12-02T11:40:17ZRivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos10.1038/s41598-018-26684-y2045-2322https://doaj.org/article/7416126acc8c476fba44f7d77dd95a752018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26684-yhttps://doaj.org/toc/2045-2322Abstract Burkholderia pseudomallei, causative agent of the often fatal disease melioidosis, dwells in tropical soils and has been found in freshwater bodies. To investigate whether rivers are potential habitats or carriers for B. pseudomallei and to assess its geographical distribution in Laos, we studied 23 rivers including the Mekong, applying culture-based detection methods and PCR to water filters and streambed sediments. B. pseudomallei was present in 9% of the rivers in the dry season and in 57% in the rainy season. We found the pathogen exclusively in Southern and Central Laos, and mainly in turbid river water, while sediments were positive in 35% of the B. pseudomallei-positive sites. Our results provide evidence for a heterogeneous temporal and spatial distribution of B. pseudomallei in rivers in Laos with a clear north-south contrast. The seasonal dynamics and predominant occurrence of B. pseudomallei in particle-rich water suggest that this pathogen is washed out with eroded soil during periods of heavy rainfall and transported by rivers, while river sediments do not seem to be permanent habitats for B. pseudomallei. Rivers may thus be useful to assess the distribution and aquatic dispersal of B. pseudomallei and other environmental pathogens in their catchment area and beyond.Rosalie E. ZimmermannOlivier RibolziAlain PierretSayaphet RattanavongMatthew T. RobinsonPaul N. NewtonViengmon DavongYves AudaJakob ZopfiDavid A. B. DanceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosalie E. Zimmermann Olivier Ribolzi Alain Pierret Sayaphet Rattanavong Matthew T. Robinson Paul N. Newton Viengmon Davong Yves Auda Jakob Zopfi David A. B. Dance Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos
description	Abstract Burkholderia pseudomallei, causative agent of the often fatal disease melioidosis, dwells in tropical soils and has been found in freshwater bodies. To investigate whether rivers are potential habitats or carriers for B. pseudomallei and to assess its geographical distribution in Laos, we studied 23 rivers including the Mekong, applying culture-based detection methods and PCR to water filters and streambed sediments. B. pseudomallei was present in 9% of the rivers in the dry season and in 57% in the rainy season. We found the pathogen exclusively in Southern and Central Laos, and mainly in turbid river water, while sediments were positive in 35% of the B. pseudomallei-positive sites. Our results provide evidence for a heterogeneous temporal and spatial distribution of B. pseudomallei in rivers in Laos with a clear north-south contrast. The seasonal dynamics and predominant occurrence of B. pseudomallei in particle-rich water suggest that this pathogen is washed out with eroded soil during periods of heavy rainfall and transported by rivers, while river sediments do not seem to be permanent habitats for B. pseudomallei. Rivers may thus be useful to assess the distribution and aquatic dispersal of B. pseudomallei and other environmental pathogens in their catchment area and beyond.
format	article
author	Rosalie E. Zimmermann Olivier Ribolzi Alain Pierret Sayaphet Rattanavong Matthew T. Robinson Paul N. Newton Viengmon Davong Yves Auda Jakob Zopfi David A. B. Dance
author_facet	Rosalie E. Zimmermann Olivier Ribolzi Alain Pierret Sayaphet Rattanavong Matthew T. Robinson Paul N. Newton Viengmon Davong Yves Auda Jakob Zopfi David A. B. Dance
author_sort	Rosalie E. Zimmermann
title	Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos
title_short	Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos
title_full	Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos
title_fullStr	Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos
title_full_unstemmed	Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos
title_sort	rivers as carriers and potential sentinels for burkholderia pseudomallei in laos
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7416126acc8c476fba44f7d77dd95a75
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Rivers as carriers and potential sentinels for Burkholderia pseudomallei in Laos

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