CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

Senescence of metabolically active cells is a process linked to ageing. Here the authors reveal that CSB is required to block replicative senescence, and epigenetic control of CSB downregulation triggers proliferative arrest in a p21-dependent manner.

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Autores principales:	Clément Crochemore, Cristina Fernández-Molina, Benjamin Montagne, Audrey Salles, Miria Ricchetti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7417a712e182448da3e35e34372714da
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spelling	oai:doaj.org-article:7417a712e182448da3e35e34372714da2021-12-02T15:35:30ZCSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence10.1038/s41467-019-13314-y2041-1723https://doaj.org/article/7417a712e182448da3e35e34372714da2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13314-yhttps://doaj.org/toc/2041-1723Senescence of metabolically active cells is a process linked to ageing. Here the authors reveal that CSB is required to block replicative senescence, and epigenetic control of CSB downregulation triggers proliferative arrest in a p21-dependent manner.Clément CrochemoreCristina Fernández-MolinaBenjamin MontagneAudrey SallesMiria RicchettiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clément Crochemore Cristina Fernández-Molina Benjamin Montagne Audrey Salles Miria Ricchetti CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
description	Senescence of metabolically active cells is a process linked to ageing. Here the authors reveal that CSB is required to block replicative senescence, and epigenetic control of CSB downregulation triggers proliferative arrest in a p21-dependent manner.
format	article
author	Clément Crochemore Cristina Fernández-Molina Benjamin Montagne Audrey Salles Miria Ricchetti
author_facet	Clément Crochemore Cristina Fernández-Molina Benjamin Montagne Audrey Salles Miria Ricchetti
author_sort	Clément Crochemore
title	CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
title_short	CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
title_full	CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
title_fullStr	CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
title_full_unstemmed	CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
title_sort	csb promoter downregulation via histone h3 hypoacetylation is an early determinant of replicative senescence
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7417a712e182448da3e35e34372714da
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CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

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