Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses

Osteoarthritis (OA) is a common condition with diverse etiologies, affecting horses, humans, and companion animals. Importantly, OA is not a single disease, but rather a disease process initiated by different events, including acute trauma, irregular or repetitive overload of articular structures, a...

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Autores principales:	Juan Estrada McDermott, Lynn Pezzanite, Laurie Goodrich, Kelly Santangelo, Lyndah Chow, Steven Dow, William Wheat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	equine osteoarthritis innate immunity macrophages Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/74226e1fcce14cb5b5a2188d13bf1ff2
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spelling	oai:doaj.org-article:74226e1fcce14cb5b5a2188d13bf1ff22021-11-25T16:19:49ZRole of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses10.3390/ani111132472076-2615https://doaj.org/article/74226e1fcce14cb5b5a2188d13bf1ff22021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3247https://doaj.org/toc/2076-2615Osteoarthritis (OA) is a common condition with diverse etiologies, affecting horses, humans, and companion animals. Importantly, OA is not a single disease, but rather a disease process initiated by different events, including acute trauma, irregular or repetitive overload of articular structures, and spontaneous development with aging. Our understanding of the pathogenesis of OA is still evolving, and OA is increasingly considered a multifactorial disease in which the innate immune system plays a key role in regulating and perpetuating low-grade inflammation, resulting in sustained cartilage injury and destruction. Macrophages within the synovium and synovial fluid are considered the key regulators of immune processes in OA and are capable of both stimulating and suppressing joint inflammation, by responding to local and systemic cues. The purpose of this review is to examine the role of the innate immune system in the overall pathogenesis of OA, drawing on insights from studies in humans, animal models of OA, and from clinical and research studies in horses. This review also discusses the various therapeutic immune modulatory options currently available for managing OA and their mechanisms of action.Juan Estrada McDermottLynn PezzaniteLaurie GoodrichKelly SantangeloLyndah ChowSteven DowWilliam WheatMDPI AGarticleequineosteoarthritisinnate immunitymacrophagesVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3247, p 3247 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	equine osteoarthritis innate immunity macrophages Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	equine osteoarthritis innate immunity macrophages Veterinary medicine SF600-1100 Zoology QL1-991 Juan Estrada McDermott Lynn Pezzanite Laurie Goodrich Kelly Santangelo Lyndah Chow Steven Dow William Wheat Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses
description	Osteoarthritis (OA) is a common condition with diverse etiologies, affecting horses, humans, and companion animals. Importantly, OA is not a single disease, but rather a disease process initiated by different events, including acute trauma, irregular or repetitive overload of articular structures, and spontaneous development with aging. Our understanding of the pathogenesis of OA is still evolving, and OA is increasingly considered a multifactorial disease in which the innate immune system plays a key role in regulating and perpetuating low-grade inflammation, resulting in sustained cartilage injury and destruction. Macrophages within the synovium and synovial fluid are considered the key regulators of immune processes in OA and are capable of both stimulating and suppressing joint inflammation, by responding to local and systemic cues. The purpose of this review is to examine the role of the innate immune system in the overall pathogenesis of OA, drawing on insights from studies in humans, animal models of OA, and from clinical and research studies in horses. This review also discusses the various therapeutic immune modulatory options currently available for managing OA and their mechanisms of action.
format	article
author	Juan Estrada McDermott Lynn Pezzanite Laurie Goodrich Kelly Santangelo Lyndah Chow Steven Dow William Wheat
author_facet	Juan Estrada McDermott Lynn Pezzanite Laurie Goodrich Kelly Santangelo Lyndah Chow Steven Dow William Wheat
author_sort	Juan Estrada McDermott
title	Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses
title_short	Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses
title_full	Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses
title_fullStr	Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses
title_full_unstemmed	Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses
title_sort	role of innate immunity in initiation and progression of osteoarthritis, with emphasis on horses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/74226e1fcce14cb5b5a2188d13bf1ff2
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Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses

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