Aptamer-based optical manipulation of protein subcellular localization in cells

Optogenetic manipulation of protein localisation in cells involves the creation of fusions that can influence activity. Here the authors develop a near-infrared light-responsive aptamer-based system to regulate the nuclear-cytoplasmic shuttling of NF-κB subunit RelA.

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Autores principales:	Sitao Xie, Yulin Du, Yu Zhang, Zhimin Wang, Dailiang Zhang, Lei He, Liping Qiu, Jianhui Jiang, Weihong Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/742312874b8542a78c33a7f1a79ba1ad
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spelling	oai:doaj.org-article:742312874b8542a78c33a7f1a79ba1ad2021-12-02T14:40:30ZAptamer-based optical manipulation of protein subcellular localization in cells10.1038/s41467-020-15113-22041-1723https://doaj.org/article/742312874b8542a78c33a7f1a79ba1ad2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15113-2https://doaj.org/toc/2041-1723Optogenetic manipulation of protein localisation in cells involves the creation of fusions that can influence activity. Here the authors develop a near-infrared light-responsive aptamer-based system to regulate the nuclear-cytoplasmic shuttling of NF-κB subunit RelA.Sitao XieYulin DuYu ZhangZhimin WangDailiang ZhangLei HeLiping QiuJianhui JiangWeihong TanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sitao Xie Yulin Du Yu Zhang Zhimin Wang Dailiang Zhang Lei He Liping Qiu Jianhui Jiang Weihong Tan Aptamer-based optical manipulation of protein subcellular localization in cells
description	Optogenetic manipulation of protein localisation in cells involves the creation of fusions that can influence activity. Here the authors develop a near-infrared light-responsive aptamer-based system to regulate the nuclear-cytoplasmic shuttling of NF-κB subunit RelA.
format	article
author	Sitao Xie Yulin Du Yu Zhang Zhimin Wang Dailiang Zhang Lei He Liping Qiu Jianhui Jiang Weihong Tan
author_facet	Sitao Xie Yulin Du Yu Zhang Zhimin Wang Dailiang Zhang Lei He Liping Qiu Jianhui Jiang Weihong Tan
author_sort	Sitao Xie
title	Aptamer-based optical manipulation of protein subcellular localization in cells
title_short	Aptamer-based optical manipulation of protein subcellular localization in cells
title_full	Aptamer-based optical manipulation of protein subcellular localization in cells
title_fullStr	Aptamer-based optical manipulation of protein subcellular localization in cells
title_full_unstemmed	Aptamer-based optical manipulation of protein subcellular localization in cells
title_sort	aptamer-based optical manipulation of protein subcellular localization in cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/742312874b8542a78c33a7f1a79ba1ad
work_keys_str_mv	AT sitaoxie aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT yulindu aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT yuzhang aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT zhiminwang aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT dailiangzhang aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT leihe aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT lipingqiu aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT jianhuijiang aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells AT weihongtan aptamerbasedopticalmanipulationofproteinsubcellularlocalizationincells
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Aptamer-based optical manipulation of protein subcellular localization in cells

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