Aptamer-based optical manipulation of protein subcellular localization in cells

Optogenetic manipulation of protein localisation in cells involves the creation of fusions that can influence activity. Here the authors develop a near-infrared light-responsive aptamer-based system to regulate the nuclear-cytoplasmic shuttling of NF-κB subunit RelA.

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Bibliographic Details
Main Authors: Sitao Xie, Yulin Du, Yu Zhang, Zhimin Wang, Dailiang Zhang, Lei He, Liping Qiu, Jianhui Jiang, Weihong Tan
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Q
Online Access:https://doaj.org/article/742312874b8542a78c33a7f1a79ba1ad
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