Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review

A malignant giant cell tumor of the bone (GCTB) is a rare primary malignant tumor classified as primary or secondary. Wide resection of the primary tumor is recommended for localized malignant GCTB, but the effect of adjuvant chemotherapy is unclear. A systematic review was performed to compare the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rokuro Morii, Shinji Tsukamoto, Alberto Righi, Kanya Honoki, Yuu Tanaka, Akira Kido, Hiromasa Fujii, Andreas F. Mavrogenis, Yasuhito Tanaka, Costantino Errani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	giant cell tumor of bone localized malignant adjuvant chemotherapy surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/74267a3d7e8d4412966e9d77119bf92e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74267a3d7e8d4412966e9d77119bf92e
record_format	dspace
spelling	oai:doaj.org-article:74267a3d7e8d4412966e9d77119bf92e2021-11-11T15:30:35ZEffect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review10.3390/cancers132154102072-6694https://doaj.org/article/74267a3d7e8d4412966e9d77119bf92e2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5410https://doaj.org/toc/2072-6694A malignant giant cell tumor of the bone (GCTB) is a rare primary malignant tumor classified as primary or secondary. Wide resection of the primary tumor is recommended for localized malignant GCTB, but the effect of adjuvant chemotherapy is unclear. A systematic review was performed to compare the mortality associated with wide resection with that of wide resection plus adjuvant chemotherapy for primary and secondary localized malignant GCTB. Among the 745 studies identified, 9 were included. A total of 112 cases of localized malignant GCTB were included, with 39 and 73 cases being primary and secondary malignant GCTB. In primary localized malignant GCTB, the mortality rates were 40% (6/15 patients) and 33% (8/24 patients) in the surgery plus adjuvant chemotherapy and surgery-only groups, respectively. Overall pooled odds ratio was 1.07 (95% confidence interval, 0.26–4.37; <i>p</i> = 0.92). In secondary localized malignant GCTB, the mortality rates were 30.6% (11/36 patients) and 62.2% (23/37 patients) in the surgery plus adjuvant chemotherapy and surgery-only groups, respectively. The overall pooled odds ratio was 0.31 (95% confidence interval, 0.10–0.95; <i>p</i> = 0.04). The effect of adjuvant chemotherapy remains unclear for primary localized malignant GCTB, but adjuvant chemotherapy improved the survival of patients with secondary localized malignant GCTB.Rokuro MoriiShinji TsukamotoAlberto RighiKanya HonokiYuu TanakaAkira KidoHiromasa FujiiAndreas F. MavrogenisYasuhito TanakaCostantino ErraniMDPI AGarticlegiant cell tumor of bonelocalizedmalignantadjuvantchemotherapysurgeryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5410, p 5410 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	giant cell tumor of bone localized malignant adjuvant chemotherapy surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	giant cell tumor of bone localized malignant adjuvant chemotherapy surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Rokuro Morii Shinji Tsukamoto Alberto Righi Kanya Honoki Yuu Tanaka Akira Kido Hiromasa Fujii Andreas F. Mavrogenis Yasuhito Tanaka Costantino Errani Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review
description	A malignant giant cell tumor of the bone (GCTB) is a rare primary malignant tumor classified as primary or secondary. Wide resection of the primary tumor is recommended for localized malignant GCTB, but the effect of adjuvant chemotherapy is unclear. A systematic review was performed to compare the mortality associated with wide resection with that of wide resection plus adjuvant chemotherapy for primary and secondary localized malignant GCTB. Among the 745 studies identified, 9 were included. A total of 112 cases of localized malignant GCTB were included, with 39 and 73 cases being primary and secondary malignant GCTB. In primary localized malignant GCTB, the mortality rates were 40% (6/15 patients) and 33% (8/24 patients) in the surgery plus adjuvant chemotherapy and surgery-only groups, respectively. Overall pooled odds ratio was 1.07 (95% confidence interval, 0.26–4.37; <i>p</i> = 0.92). In secondary localized malignant GCTB, the mortality rates were 30.6% (11/36 patients) and 62.2% (23/37 patients) in the surgery plus adjuvant chemotherapy and surgery-only groups, respectively. The overall pooled odds ratio was 0.31 (95% confidence interval, 0.10–0.95; <i>p</i> = 0.04). The effect of adjuvant chemotherapy remains unclear for primary localized malignant GCTB, but adjuvant chemotherapy improved the survival of patients with secondary localized malignant GCTB.
format	article
author	Rokuro Morii Shinji Tsukamoto Alberto Righi Kanya Honoki Yuu Tanaka Akira Kido Hiromasa Fujii Andreas F. Mavrogenis Yasuhito Tanaka Costantino Errani
author_facet	Rokuro Morii Shinji Tsukamoto Alberto Righi Kanya Honoki Yuu Tanaka Akira Kido Hiromasa Fujii Andreas F. Mavrogenis Yasuhito Tanaka Costantino Errani
author_sort	Rokuro Morii
title	Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review
title_short	Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review
title_full	Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review
title_fullStr	Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review
title_full_unstemmed	Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review
title_sort	effect of adjuvant chemotherapy on localized malignant giant cell tumor of bone: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/74267a3d7e8d4412966e9d77119bf92e
work_keys_str_mv	AT rokuromorii effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT shinjitsukamoto effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT albertorighi effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT kanyahonoki effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT yuutanaka effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT akirakido effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT hiromasafujii effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT andreasfmavrogenis effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT yasuhitotanaka effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview AT costantinoerrani effectofadjuvantchemotherapyonlocalizedmalignantgiantcelltumorofboneasystematicreview
_version_	1718435245410222080

Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review

Ejemplares similares