Crystal structure of NOD2 and its implications in human disease

NOD2 has a role in host innate immune responses, activating the NF-κB signalling pathway and mutations have been associated with chronic inflammatory disorders. Here, Maekawa et al. solved the structure of NOD2 in its inactive form, suggesting a mechanism for autoinhibition.

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Autores principales:	Sakiko Maekawa, Umeharu Ohto, Takuma Shibata, Kensuke Miyake, Toshiyuki Shimizu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7427180e5bf844dd9f3a66b77937b088
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spelling	oai:doaj.org-article:7427180e5bf844dd9f3a66b77937b0882021-12-02T16:49:43ZCrystal structure of NOD2 and its implications in human disease10.1038/ncomms118132041-1723https://doaj.org/article/7427180e5bf844dd9f3a66b77937b0882016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11813https://doaj.org/toc/2041-1723NOD2 has a role in host innate immune responses, activating the NF-κB signalling pathway and mutations have been associated with chronic inflammatory disorders. Here, Maekawa et al. solved the structure of NOD2 in its inactive form, suggesting a mechanism for autoinhibition.Sakiko MaekawaUmeharu OhtoTakuma ShibataKensuke MiyakeToshiyuki ShimizuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sakiko Maekawa Umeharu Ohto Takuma Shibata Kensuke Miyake Toshiyuki Shimizu Crystal structure of NOD2 and its implications in human disease
description	NOD2 has a role in host innate immune responses, activating the NF-κB signalling pathway and mutations have been associated with chronic inflammatory disorders. Here, Maekawa et al. solved the structure of NOD2 in its inactive form, suggesting a mechanism for autoinhibition.
format	article
author	Sakiko Maekawa Umeharu Ohto Takuma Shibata Kensuke Miyake Toshiyuki Shimizu
author_facet	Sakiko Maekawa Umeharu Ohto Takuma Shibata Kensuke Miyake Toshiyuki Shimizu
author_sort	Sakiko Maekawa
title	Crystal structure of NOD2 and its implications in human disease
title_short	Crystal structure of NOD2 and its implications in human disease
title_full	Crystal structure of NOD2 and its implications in human disease
title_fullStr	Crystal structure of NOD2 and its implications in human disease
title_full_unstemmed	Crystal structure of NOD2 and its implications in human disease
title_sort	crystal structure of nod2 and its implications in human disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7427180e5bf844dd9f3a66b77937b088
work_keys_str_mv	AT sakikomaekawa crystalstructureofnod2anditsimplicationsinhumandisease AT umeharuohto crystalstructureofnod2anditsimplicationsinhumandisease AT takumashibata crystalstructureofnod2anditsimplicationsinhumandisease AT kensukemiyake crystalstructureofnod2anditsimplicationsinhumandisease AT toshiyukishimizu crystalstructureofnod2anditsimplicationsinhumandisease
_version_	1718383222179495936

Crystal structure of NOD2 and its implications in human disease

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