Crystal structure of NOD2 and its implications in human disease
NOD2 has a role in host innate immune responses, activating the NF-κB signalling pathway and mutations have been associated with chronic inflammatory disorders. Here, Maekawa et al. solved the structure of NOD2 in its inactive form, suggesting a mechanism for autoinhibition.
Guardado en:
Autores principales: | Sakiko Maekawa, Umeharu Ohto, Takuma Shibata, Kensuke Miyake, Toshiyuki Shimizu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
|
Materias: | |
Acceso en línea: | https://doaj.org/article/7427180e5bf844dd9f3a66b77937b088 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga
por: Yuqun Xu, et al.
Publicado: (2018) -
Crystal structure of a thermophilic fungal cyanase and its implications on the catalytic mechanism for bioremediation
por: Bibhuti Ranjan, et al.
Publicado: (2021) -
NOD2 and inflammation: current insights
por: Negroni A, et al.
Publicado: (2018) -
Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction
por: Ivan Rodriguez-Nunez, et al.
Publicado: (2017) -
NOD1 modulates IL-10 signalling in human dendritic cells
por: Theresa Neuper, et al.
Publicado: (2017)