Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.

Spatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here with a group of older adults (n = 56, 58-80 (67.9±5.2) year old, 31 females, 18.7±3.6 years of education), we...

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Autores principales:	Xiong Jiang, James H Howard, G William Rebeck, Raymond Scott Turner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/742a30dabad84377ad5ab5e2b59ce884
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spelling	oai:doaj.org-article:742a30dabad84377ad5ab5e2b59ce8842021-12-02T20:15:49ZSpatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.1932-620310.1371/journal.pone.0252958https://doaj.org/article/742a30dabad84377ad5ab5e2b59ce8842021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252958https://doaj.org/toc/1932-6203Spatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here with a group of older adults (n = 56, 58-80 (67.9±5.2) year old, 31 females, 18.7±3.6 years of education), we provide evidence supporting the notion that spatial IOR is mildly impaired in individuals with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD), and the impairment is detectable using a double cue paradigm. Furthermore, reduced spatial IOR in high-risk healthy older individuals is associated with reduced memory and other neurocognitive task performance, suggesting that the double cue spatial IOR paradigm may be useful in detecting MCI and early AD.Xiong JiangJames H HowardG William RebeckRaymond Scott TurnerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252958 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiong Jiang James H Howard G William Rebeck Raymond Scott Turner Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.
description	Spatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here with a group of older adults (n = 56, 58-80 (67.9±5.2) year old, 31 females, 18.7±3.6 years of education), we provide evidence supporting the notion that spatial IOR is mildly impaired in individuals with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD), and the impairment is detectable using a double cue paradigm. Furthermore, reduced spatial IOR in high-risk healthy older individuals is associated with reduced memory and other neurocognitive task performance, suggesting that the double cue spatial IOR paradigm may be useful in detecting MCI and early AD.
format	article
author	Xiong Jiang James H Howard G William Rebeck Raymond Scott Turner
author_facet	Xiong Jiang James H Howard G William Rebeck Raymond Scott Turner
author_sort	Xiong Jiang
title	Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.
title_short	Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.
title_full	Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.
title_fullStr	Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.
title_full_unstemmed	Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.
title_sort	spatial inhibition of return is impaired in mild cognitive impairment and mild alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/742a30dabad84377ad5ab5e2b59ce884
work_keys_str_mv	AT xiongjiang spatialinhibitionofreturnisimpairedinmildcognitiveimpairmentandmildalzheimersdisease AT jameshhoward spatialinhibitionofreturnisimpairedinmildcognitiveimpairmentandmildalzheimersdisease AT gwilliamrebeck spatialinhibitionofreturnisimpairedinmildcognitiveimpairmentandmildalzheimersdisease AT raymondscottturner spatialinhibitionofreturnisimpairedinmildcognitiveimpairmentandmildalzheimersdisease
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Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.

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