Chemical genomics reveals histone deacetylases are required for core regulatory transcription

Core regulatory transcription factors are usually regulated by cell-type specific super enhancers (SEs). Here, the authors screen for chemical probes able to distinguish between SE-driven and promoter-driven transcription and find that histone deacetylases are selectively required for core regulator...

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Autores principales:	Berkley E. Gryder, Lei Wu, Girma M. Woldemichael, Silvia Pomella, Taylor R. Quinn, Paul M. C. Park, Abigail Cleveland, Benjamin Z. Stanton, Young Song, Rossella Rota, Olaf Wiest, Marielle E. Yohe, Jack F. Shern, Jun Qi, Javed Khan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/742c055d88f34a9a94fff834255a1649
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spelling	oai:doaj.org-article:742c055d88f34a9a94fff834255a16492021-12-02T14:40:21ZChemical genomics reveals histone deacetylases are required for core regulatory transcription10.1038/s41467-019-11046-72041-1723https://doaj.org/article/742c055d88f34a9a94fff834255a16492019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11046-7https://doaj.org/toc/2041-1723Core regulatory transcription factors are usually regulated by cell-type specific super enhancers (SEs). Here, the authors screen for chemical probes able to distinguish between SE-driven and promoter-driven transcription and find that histone deacetylases are selectively required for core regulatory transcription.Berkley E. GryderLei WuGirma M. WoldemichaelSilvia PomellaTaylor R. QuinnPaul M. C. ParkAbigail ClevelandBenjamin Z. StantonYoung SongRossella RotaOlaf WiestMarielle E. YoheJack F. ShernJun QiJaved KhanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Berkley E. Gryder Lei Wu Girma M. Woldemichael Silvia Pomella Taylor R. Quinn Paul M. C. Park Abigail Cleveland Benjamin Z. Stanton Young Song Rossella Rota Olaf Wiest Marielle E. Yohe Jack F. Shern Jun Qi Javed Khan Chemical genomics reveals histone deacetylases are required for core regulatory transcription
description	Core regulatory transcription factors are usually regulated by cell-type specific super enhancers (SEs). Here, the authors screen for chemical probes able to distinguish between SE-driven and promoter-driven transcription and find that histone deacetylases are selectively required for core regulatory transcription.
format	article
author	Berkley E. Gryder Lei Wu Girma M. Woldemichael Silvia Pomella Taylor R. Quinn Paul M. C. Park Abigail Cleveland Benjamin Z. Stanton Young Song Rossella Rota Olaf Wiest Marielle E. Yohe Jack F. Shern Jun Qi Javed Khan
author_facet	Berkley E. Gryder Lei Wu Girma M. Woldemichael Silvia Pomella Taylor R. Quinn Paul M. C. Park Abigail Cleveland Benjamin Z. Stanton Young Song Rossella Rota Olaf Wiest Marielle E. Yohe Jack F. Shern Jun Qi Javed Khan
author_sort	Berkley E. Gryder
title	Chemical genomics reveals histone deacetylases are required for core regulatory transcription
title_short	Chemical genomics reveals histone deacetylases are required for core regulatory transcription
title_full	Chemical genomics reveals histone deacetylases are required for core regulatory transcription
title_fullStr	Chemical genomics reveals histone deacetylases are required for core regulatory transcription
title_full_unstemmed	Chemical genomics reveals histone deacetylases are required for core regulatory transcription
title_sort	chemical genomics reveals histone deacetylases are required for core regulatory transcription
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/742c055d88f34a9a94fff834255a1649
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Chemical genomics reveals histone deacetylases are required for core regulatory transcription

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