Engineering subtilisin proteases that specifically degrade active RAS
Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engineered to cleave this region degraded RAS in vitro...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
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Nature Portfolio
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6 |
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