Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform overexpressed in several cancers that has been implicated in drug resistance. Here the authors identify a small molecule inhibitor of GSTO1 that effectively inhibits tumor growth in colon cancer models, and establish its mechanism...

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Autores principales:	Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura, Elizabeth Ziemke, Jeanne A. Stuckey, Si Li, Krishnapriya Chinnaswamy, Hiroyuki Otake, Bikash Debnath, Vladimir Yarovenko, Judith S. Sebolt-Leopold, Mats Ljungman, Nouri Neamati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7431badb33544578ba6eb5990f3bb58e
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spelling	oai:doaj.org-article:7431badb33544578ba6eb5990f3bb58e2021-12-02T14:40:16ZMechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor10.1038/ncomms130842041-1723https://doaj.org/article/7431badb33544578ba6eb5990f3bb58e2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13084https://doaj.org/toc/2041-1723Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform overexpressed in several cancers that has been implicated in drug resistance. Here the authors identify a small molecule inhibitor of GSTO1 that effectively inhibits tumor growth in colon cancer models, and establish its mechanism of action.Kavya RamkumarSoma SamantaAnahita KyaniSuhui YangShuzo TamuraElizabeth ZiemkeJeanne A. StuckeySi LiKrishnapriya ChinnaswamyHiroyuki OtakeBikash DebnathVladimir YarovenkoJudith S. Sebolt-LeopoldMats LjungmanNouri NeamatiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kavya Ramkumar Soma Samanta Anahita Kyani Suhui Yang Shuzo Tamura Elizabeth Ziemke Jeanne A. Stuckey Si Li Krishnapriya Chinnaswamy Hiroyuki Otake Bikash Debnath Vladimir Yarovenko Judith S. Sebolt-Leopold Mats Ljungman Nouri Neamati Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
description	Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform overexpressed in several cancers that has been implicated in drug resistance. Here the authors identify a small molecule inhibitor of GSTO1 that effectively inhibits tumor growth in colon cancer models, and establish its mechanism of action.
format	article
author	Kavya Ramkumar Soma Samanta Anahita Kyani Suhui Yang Shuzo Tamura Elizabeth Ziemke Jeanne A. Stuckey Si Li Krishnapriya Chinnaswamy Hiroyuki Otake Bikash Debnath Vladimir Yarovenko Judith S. Sebolt-Leopold Mats Ljungman Nouri Neamati
author_facet	Kavya Ramkumar Soma Samanta Anahita Kyani Suhui Yang Shuzo Tamura Elizabeth Ziemke Jeanne A. Stuckey Si Li Krishnapriya Chinnaswamy Hiroyuki Otake Bikash Debnath Vladimir Yarovenko Judith S. Sebolt-Leopold Mats Ljungman Nouri Neamati
author_sort	Kavya Ramkumar
title	Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
title_short	Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
title_full	Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
title_fullStr	Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
title_full_unstemmed	Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
title_sort	mechanistic evaluation and transcriptional signature of a glutathione s-transferase omega 1 inhibitor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7431badb33544578ba6eb5990f3bb58e
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Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

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