Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex

Abstract To examine episodic memory in rats, we trained rats to perform two tasks and tested them for memory of past self-behavior without making them expect to be asked about the memory later when encoding. One of the trained tasks was a delayed matching-to-position task in which the rats were requ...

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Autor principal:	Nobuya Sato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7433246287184f15a7e86828d348f801
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spelling	oai:doaj.org-article:7433246287184f15a7e86828d348f8012021-12-02T13:57:37ZEpisodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex10.1038/s41598-021-81943-92045-2322https://doaj.org/article/7433246287184f15a7e86828d348f8012021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81943-9https://doaj.org/toc/2045-2322Abstract To examine episodic memory in rats, we trained rats to perform two tasks and tested them for memory of past self-behavior without making them expect to be asked about the memory later when encoding. One of the trained tasks was a delayed matching-to-position task in which the rats were required to remember the location of a presented lever. The other was a tone discrimination task in which the rats were required to discriminate between two pure tones. After learning both tasks, the rats were unexpectedly asked the location of the pressed lever after responding to the cue tone in probe trials during test sessions. The rats demonstrated a response bias that suggests that they have the ability to retrospectively recollect their self-behavior, i.e., episodic memory. We next made excitotoxic lesions in the retrosplenial cortex (RSC) and investigated the effects of the lesions on the unexpected recollection. In the rats with lesions of the RSC, the response bias disappeared. This suggests that the RSC has a role in retrospectively answering unexpected questions about self-behavior.Nobuya SatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nobuya Sato Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex
description	Abstract To examine episodic memory in rats, we trained rats to perform two tasks and tested them for memory of past self-behavior without making them expect to be asked about the memory later when encoding. One of the trained tasks was a delayed matching-to-position task in which the rats were required to remember the location of a presented lever. The other was a tone discrimination task in which the rats were required to discriminate between two pure tones. After learning both tasks, the rats were unexpectedly asked the location of the pressed lever after responding to the cue tone in probe trials during test sessions. The rats demonstrated a response bias that suggests that they have the ability to retrospectively recollect their self-behavior, i.e., episodic memory. We next made excitotoxic lesions in the retrosplenial cortex (RSC) and investigated the effects of the lesions on the unexpected recollection. In the rats with lesions of the RSC, the response bias disappeared. This suggests that the RSC has a role in retrospectively answering unexpected questions about self-behavior.
format	article
author	Nobuya Sato
author_facet	Nobuya Sato
author_sort	Nobuya Sato
title	Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex
title_short	Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex
title_full	Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex
title_fullStr	Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex
title_full_unstemmed	Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex
title_sort	episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7433246287184f15a7e86828d348f801
work_keys_str_mv	AT nobuyasato episodiclikememoryofratsasretrospectiveretrievalofincidentallyencodedlocationsandinvolvementoftheretrosplenialcortex
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Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex

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