Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study

Chronic obstructive lung disease: Variations in disease progression Patients with chronic obstructive pulmonary disease (COPD) who suffer from frequent exacerbations do not necessarily persist with such severity over time. Exacerbations in COPD are defined by worsening respiratory symptoms that resu...

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Autores principales:	Mette Reilev, Jesper Lykkegaard, Anders Halling, Jørgen Vestbo, Jens Søndergaard, Anton Pottegård
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/74359b8523d24b0e9c55fabbffdd7fc2
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spelling	oai:doaj.org-article:74359b8523d24b0e9c55fabbffdd7fc22021-12-02T16:19:46ZStability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study10.1038/s41533-017-0029-72055-1010https://doaj.org/article/74359b8523d24b0e9c55fabbffdd7fc22017-04-01T00:00:00Zhttps://doi.org/10.1038/s41533-017-0029-7https://doaj.org/toc/2055-1010Chronic obstructive lung disease: Variations in disease progression Patients with chronic obstructive pulmonary disease (COPD) who suffer from frequent exacerbations do not necessarily persist with such severity over time. Exacerbations in COPD are defined by worsening respiratory symptoms that result in changes to treatment, hospitalization and, at worst, death. However, clarity is needed on whether frequent exacerbations is a stable feature of some patients’ disease. Mette Reilev at the University of Southern Denmark and co-workers followed, over 10 years, 19,752 COPD patients living in Denmark who suffered at least one exacerbation in 2003. By 2004, 60% of patients were classed as infrequent or non-exacerbators, rising to 68% by 2012. Very few patients remained “frequent exacerbators”, suggesting the rate of exacerbations changes considerably over time. This could hold implications for COPD treatment and challenge assumptions made about disease progression.Mette ReilevJesper LykkegaardAnders HallingJørgen VestboJens SøndergaardAnton PottegårdNature PortfolioarticleDiseases of the respiratory systemRC705-779ENnpj Primary Care Respiratory Medicine, Vol 27, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Mette Reilev Jesper Lykkegaard Anders Halling Jørgen Vestbo Jens Søndergaard Anton Pottegård Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study
description	Chronic obstructive lung disease: Variations in disease progression Patients with chronic obstructive pulmonary disease (COPD) who suffer from frequent exacerbations do not necessarily persist with such severity over time. Exacerbations in COPD are defined by worsening respiratory symptoms that result in changes to treatment, hospitalization and, at worst, death. However, clarity is needed on whether frequent exacerbations is a stable feature of some patients’ disease. Mette Reilev at the University of Southern Denmark and co-workers followed, over 10 years, 19,752 COPD patients living in Denmark who suffered at least one exacerbation in 2003. By 2004, 60% of patients were classed as infrequent or non-exacerbators, rising to 68% by 2012. Very few patients remained “frequent exacerbators”, suggesting the rate of exacerbations changes considerably over time. This could hold implications for COPD treatment and challenge assumptions made about disease progression.
format	article
author	Mette Reilev Jesper Lykkegaard Anders Halling Jørgen Vestbo Jens Søndergaard Anton Pottegård
author_facet	Mette Reilev Jesper Lykkegaard Anders Halling Jørgen Vestbo Jens Søndergaard Anton Pottegård
author_sort	Mette Reilev
title	Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study
title_short	Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study
title_full	Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study
title_fullStr	Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study
title_full_unstemmed	Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study
title_sort	stability of the frequent copd exacerbator in the general population: a danish nationwide register-based study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/74359b8523d24b0e9c55fabbffdd7fc2
work_keys_str_mv	AT mettereilev stabilityofthefrequentcopdexacerbatorinthegeneralpopulationadanishnationwideregisterbasedstudy AT jesperlykkegaard stabilityofthefrequentcopdexacerbatorinthegeneralpopulationadanishnationwideregisterbasedstudy AT andershalling stabilityofthefrequentcopdexacerbatorinthegeneralpopulationadanishnationwideregisterbasedstudy AT jørgenvestbo stabilityofthefrequentcopdexacerbatorinthegeneralpopulationadanishnationwideregisterbasedstudy AT jenssøndergaard stabilityofthefrequentcopdexacerbatorinthegeneralpopulationadanishnationwideregisterbasedstudy AT antonpottegard stabilityofthefrequentcopdexacerbatorinthegeneralpopulationadanishnationwideregisterbasedstudy
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Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study

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