Genome-wide chromatin accessibility is restricted by ANP32E

Chromatin state underlies cellular function, and transcription factor binding patterns along with epigenetic marks define chromatin state. Here the authors show that the histone chaperone ANP32E functions through regulation of H2A.Z to restrict genome-wide chromatin accessibility and to inhibit gene...

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Auteurs principaux:	Kristin E. Murphy, Fanju W. Meng, Claire E. Makowski, Patrick J. Murphy
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/743c4f320d424be182bff020e0814e30
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id	oai:doaj.org-article:743c4f320d424be182bff020e0814e30
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spelling	oai:doaj.org-article:743c4f320d424be182bff020e0814e302021-12-02T19:16:29ZGenome-wide chromatin accessibility is restricted by ANP32E10.1038/s41467-020-18821-x2041-1723https://doaj.org/article/743c4f320d424be182bff020e0814e302020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18821-xhttps://doaj.org/toc/2041-1723Chromatin state underlies cellular function, and transcription factor binding patterns along with epigenetic marks define chromatin state. Here the authors show that the histone chaperone ANP32E functions through regulation of H2A.Z to restrict genome-wide chromatin accessibility and to inhibit gene transcriptional activation.Kristin E. MurphyFanju W. MengClaire E. MakowskiPatrick J. MurphyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristin E. Murphy Fanju W. Meng Claire E. Makowski Patrick J. Murphy Genome-wide chromatin accessibility is restricted by ANP32E
description	Chromatin state underlies cellular function, and transcription factor binding patterns along with epigenetic marks define chromatin state. Here the authors show that the histone chaperone ANP32E functions through regulation of H2A.Z to restrict genome-wide chromatin accessibility and to inhibit gene transcriptional activation.
format	article
author	Kristin E. Murphy Fanju W. Meng Claire E. Makowski Patrick J. Murphy
author_facet	Kristin E. Murphy Fanju W. Meng Claire E. Makowski Patrick J. Murphy
author_sort	Kristin E. Murphy
title	Genome-wide chromatin accessibility is restricted by ANP32E
title_short	Genome-wide chromatin accessibility is restricted by ANP32E
title_full	Genome-wide chromatin accessibility is restricted by ANP32E
title_fullStr	Genome-wide chromatin accessibility is restricted by ANP32E
title_full_unstemmed	Genome-wide chromatin accessibility is restricted by ANP32E
title_sort	genome-wide chromatin accessibility is restricted by anp32e
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/743c4f320d424be182bff020e0814e30
work_keys_str_mv	AT kristinemurphy genomewidechromatinaccessibilityisrestrictedbyanp32e AT fanjuwmeng genomewidechromatinaccessibilityisrestrictedbyanp32e AT claireemakowski genomewidechromatinaccessibilityisrestrictedbyanp32e AT patrickjmurphy genomewidechromatinaccessibilityisrestrictedbyanp32e
_version_	1718376919196499968

Genome-wide chromatin accessibility is restricted by ANP32E

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