INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS

Abstract. Using modern immunological methods of studies, we investigated some immunopathogenetic aspects of rheumatoid arthritis complicated by chronic herpesvirus infection. It was established that both rheumatoid arthritis, and chronic herpesvirus infection are accompanied by pronounced imbalance...

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Autores principales:	N. A. Pronina, V. S. Sviridova, E. N. Kologrivova, L. V. Еliseeva, I. O. Naslednikova, O. I. Urazova, V. V. Novitsky, O. V. Voronkova, N. A. Sukhalentseva, E. B. Gorbunova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	herpes simplex virus rheumatoid arthritis cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/743e87519dbd4af2b88301538f9ed66d
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spelling	oai:doaj.org-article:743e87519dbd4af2b88301538f9ed66d2021-11-18T08:03:41ZINFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2009-1-91-94https://doaj.org/article/743e87519dbd4af2b88301538f9ed66d2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/465https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Using modern immunological methods of studies, we investigated some immunopathogenetic aspects of rheumatoid arthritis complicated by chronic herpesvirus infection. It was established that both rheumatoid arthritis, and chronic herpesvirus infection are accompanied by pronounced imbalance in production of immunoregulatory Th1/Th2-cytokines produced in immunocompetent cells of peripheral blood. In case of rheumatoid arthritis combined with herpes simplex infection, IL-2 and IFNγγ levels were decreased, whereas IL-4 и IL-6 levels proved to be increased, as compared with isolated diseases under study.N. A. ProninaV. S. SviridovaE. N. KologrivovaL. V. ЕliseevaI. O. NaslednikovaO. I. UrazovaV. V. NovitskyO. V. VoronkovaN. A. SukhalentsevaE. B. GorbunovaSPb RAACIarticleherpes simplex virusrheumatoid arthritiscytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 1, Pp 91-94 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	herpes simplex virus rheumatoid arthritis cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	herpes simplex virus rheumatoid arthritis cytokines Immunologic diseases. Allergy RC581-607 N. A. Pronina V. S. Sviridova E. N. Kologrivova L. V. Еliseeva I. O. Naslednikova O. I. Urazova V. V. Novitsky O. V. Voronkova N. A. Sukhalentseva E. B. Gorbunova INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS
description	Abstract. Using modern immunological methods of studies, we investigated some immunopathogenetic aspects of rheumatoid arthritis complicated by chronic herpesvirus infection. It was established that both rheumatoid arthritis, and chronic herpesvirus infection are accompanied by pronounced imbalance in production of immunoregulatory Th1/Th2-cytokines produced in immunocompetent cells of peripheral blood. In case of rheumatoid arthritis combined with herpes simplex infection, IL-2 and IFNγγ levels were decreased, whereas IL-4 и IL-6 levels proved to be increased, as compared with isolated diseases under study.
format	article
author	N. A. Pronina V. S. Sviridova E. N. Kologrivova L. V. Еliseeva I. O. Naslednikova O. I. Urazova V. V. Novitsky O. V. Voronkova N. A. Sukhalentseva E. B. Gorbunova
author_facet	N. A. Pronina V. S. Sviridova E. N. Kologrivova L. V. Еliseeva I. O. Naslednikova O. I. Urazova V. V. Novitsky O. V. Voronkova N. A. Sukhalentseva E. B. Gorbunova
author_sort	N. A. Pronina
title	INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS
title_short	INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS
title_full	INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS
title_fullStr	INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS
title_full_unstemmed	INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS
title_sort	influence of herpes simplex virus persistence upon production of cytokines by immunocompetent cells in rheumatoid arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/743e87519dbd4af2b88301538f9ed66d
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INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS

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