Under-dominance constrains the evolution of negative autoregulation in diploids.

Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change. Theoretical work and empirical investigation in Escherichia coli have shown that negative autoregulatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexander J Stewart, Robert M Seymour, Andrew Pomiankowski, Max Reuter
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/743f062e6c674f6187f9401a65a88c92
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:743f062e6c674f6187f9401a65a88c92
record_format	dspace
spelling	oai:doaj.org-article:743f062e6c674f6187f9401a65a88c922021-11-18T05:52:18ZUnder-dominance constrains the evolution of negative autoregulation in diploids.1553-734X1553-735810.1371/journal.pcbi.1002992https://doaj.org/article/743f062e6c674f6187f9401a65a88c922013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555226/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change. Theoretical work and empirical investigation in Escherichia coli have shown that negative autoregulation confers both rapid response times and reduced intrinsic noise, which is reflected in the fact that almost half of Escherichia coli transcription factors are negatively autoregulated. However, negative autoregulation is rare amongst the transcription factors of Saccharomyces cerevisiae. This difference is surprising because E. coli and S. cerevisiae otherwise have similar profiles of network motifs. In this study we investigate regulatory interactions amongst the transcription factors of Drosophila melanogaster and humans, and show that they have a similar dearth of negative autoregulation to that seen in S. cerevisiae. We then present a model demonstrating that this striking difference in the noise reduction strategies used amongst species can be explained by constraints on the evolution of negative autoregulation in diploids. We show that regulatory interactions between pairs of homologous genes within the same cell can lead to under-dominance--mutations which result in stronger autoregulation, and decrease noise in homozygotes, paradoxically can cause increased noise in heterozygotes. This severely limits a diploid's ability to evolve negative autoregulation as a noise reduction mechanism. Our work offers a simple and general explanation for a previously unexplained difference between the regulatory architectures of E. coli and yeast, Drosophila and humans. It also demonstrates that the effects of diploidy in gene networks can have counter-intuitive consequences that may profoundly influence the course of evolution.Alexander J StewartRobert M SeymourAndrew PomiankowskiMax ReuterPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 3, p e1002992 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alexander J Stewart Robert M Seymour Andrew Pomiankowski Max Reuter Under-dominance constrains the evolution of negative autoregulation in diploids.
description	Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change. Theoretical work and empirical investigation in Escherichia coli have shown that negative autoregulation confers both rapid response times and reduced intrinsic noise, which is reflected in the fact that almost half of Escherichia coli transcription factors are negatively autoregulated. However, negative autoregulation is rare amongst the transcription factors of Saccharomyces cerevisiae. This difference is surprising because E. coli and S. cerevisiae otherwise have similar profiles of network motifs. In this study we investigate regulatory interactions amongst the transcription factors of Drosophila melanogaster and humans, and show that they have a similar dearth of negative autoregulation to that seen in S. cerevisiae. We then present a model demonstrating that this striking difference in the noise reduction strategies used amongst species can be explained by constraints on the evolution of negative autoregulation in diploids. We show that regulatory interactions between pairs of homologous genes within the same cell can lead to under-dominance--mutations which result in stronger autoregulation, and decrease noise in homozygotes, paradoxically can cause increased noise in heterozygotes. This severely limits a diploid's ability to evolve negative autoregulation as a noise reduction mechanism. Our work offers a simple and general explanation for a previously unexplained difference between the regulatory architectures of E. coli and yeast, Drosophila and humans. It also demonstrates that the effects of diploidy in gene networks can have counter-intuitive consequences that may profoundly influence the course of evolution.
format	article
author	Alexander J Stewart Robert M Seymour Andrew Pomiankowski Max Reuter
author_facet	Alexander J Stewart Robert M Seymour Andrew Pomiankowski Max Reuter
author_sort	Alexander J Stewart
title	Under-dominance constrains the evolution of negative autoregulation in diploids.
title_short	Under-dominance constrains the evolution of negative autoregulation in diploids.
title_full	Under-dominance constrains the evolution of negative autoregulation in diploids.
title_fullStr	Under-dominance constrains the evolution of negative autoregulation in diploids.
title_full_unstemmed	Under-dominance constrains the evolution of negative autoregulation in diploids.
title_sort	under-dominance constrains the evolution of negative autoregulation in diploids.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/743f062e6c674f6187f9401a65a88c92
work_keys_str_mv	AT alexanderjstewart underdominanceconstrainstheevolutionofnegativeautoregulationindiploids AT robertmseymour underdominanceconstrainstheevolutionofnegativeautoregulationindiploids AT andrewpomiankowski underdominanceconstrainstheevolutionofnegativeautoregulationindiploids AT maxreuter underdominanceconstrainstheevolutionofnegativeautoregulationindiploids
_version_	1718424736046776320

Under-dominance constrains the evolution of negative autoregulation in diploids.

Ejemplares similares