Application of metagenomics in the diagnosis of ophthalmic diseases

In recent years, metagenomics(MGS)is the fastest growing fields in microbiology, and has been broadly applied in the detection of pathogenic microorganisms. Comparing with the traditional poly merase chain reaction(PCR)-based detecting technology which relies on microbial culture, MGS can directly d...

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Autores principales:	Jin-Xia Yu, Ying Wang, Jian-Xia Hao, Yan-E Gao, Hong-Sheng Bi, Xiao-Feng Xie
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	metagenomics pathogenic microorganism keratitis dry eye endoophthalmitis uveitis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/743f877b89f24e38afccc001311d8301
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spelling	oai:doaj.org-article:743f877b89f24e38afccc001311d83012021-11-22T14:22:32ZApplication of metagenomics in the diagnosis of ophthalmic diseases1672-512310.3980/j.issn.1672-5123.2021.12.13https://doaj.org/article/743f877b89f24e38afccc001311d83012021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112013.pdfhttps://doaj.org/toc/1672-5123In recent years, metagenomics(MGS)is the fastest growing fields in microbiology, and has been broadly applied in the detection of pathogenic microorganisms. Comparing with the traditional poly merase chain reaction(PCR)-based detecting technology which relies on microbial culture, MGS can directly detect the sequences of the total microbial DNA from uncultured samples with the high-throughput sequencing platform. It can help the doctors identify the involved pathogens more quickly and provide better medication guidance. Among the known ophthalmic diseases, a lot of them are caused by the infection of pathogens and have many difficulties in clinical diagnosis and treatment. The development of metagenomics provides us a more effective and reliable way for detecting the pathogens of ophthalmic diseases. This article was aimed to review the development of MGS, applications and in the field of ophthalmology, as well as its current deficiencies and the possible development directions in the future.Jin-Xia YuYing WangJian-Xia HaoYan-E GaoHong-Sheng BiXiao-Feng XiePress of International Journal of Ophthalmology (IJO PRESS)articlemetagenomicspathogenic microorganismkeratitisdry eyeendoophthalmitisuveitisOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2090-2095 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metagenomics pathogenic microorganism keratitis dry eye endoophthalmitis uveitis Ophthalmology RE1-994
spellingShingle	metagenomics pathogenic microorganism keratitis dry eye endoophthalmitis uveitis Ophthalmology RE1-994 Jin-Xia Yu Ying Wang Jian-Xia Hao Yan-E Gao Hong-Sheng Bi Xiao-Feng Xie Application of metagenomics in the diagnosis of ophthalmic diseases
description	In recent years, metagenomics(MGS)is the fastest growing fields in microbiology, and has been broadly applied in the detection of pathogenic microorganisms. Comparing with the traditional poly merase chain reaction(PCR)-based detecting technology which relies on microbial culture, MGS can directly detect the sequences of the total microbial DNA from uncultured samples with the high-throughput sequencing platform. It can help the doctors identify the involved pathogens more quickly and provide better medication guidance. Among the known ophthalmic diseases, a lot of them are caused by the infection of pathogens and have many difficulties in clinical diagnosis and treatment. The development of metagenomics provides us a more effective and reliable way for detecting the pathogens of ophthalmic diseases. This article was aimed to review the development of MGS, applications and in the field of ophthalmology, as well as its current deficiencies and the possible development directions in the future.
format	article
author	Jin-Xia Yu Ying Wang Jian-Xia Hao Yan-E Gao Hong-Sheng Bi Xiao-Feng Xie
author_facet	Jin-Xia Yu Ying Wang Jian-Xia Hao Yan-E Gao Hong-Sheng Bi Xiao-Feng Xie
author_sort	Jin-Xia Yu
title	Application of metagenomics in the diagnosis of ophthalmic diseases
title_short	Application of metagenomics in the diagnosis of ophthalmic diseases
title_full	Application of metagenomics in the diagnosis of ophthalmic diseases
title_fullStr	Application of metagenomics in the diagnosis of ophthalmic diseases
title_full_unstemmed	Application of metagenomics in the diagnosis of ophthalmic diseases
title_sort	application of metagenomics in the diagnosis of ophthalmic diseases
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/743f877b89f24e38afccc001311d8301
work_keys_str_mv	AT jinxiayu applicationofmetagenomicsinthediagnosisofophthalmicdiseases AT yingwang applicationofmetagenomicsinthediagnosisofophthalmicdiseases AT jianxiahao applicationofmetagenomicsinthediagnosisofophthalmicdiseases AT yanegao applicationofmetagenomicsinthediagnosisofophthalmicdiseases AT hongshengbi applicationofmetagenomicsinthediagnosisofophthalmicdiseases AT xiaofengxie applicationofmetagenomicsinthediagnosisofophthalmicdiseases
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Application of metagenomics in the diagnosis of ophthalmic diseases

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