The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits

Abstract Rates of non-communicable diseases (NCDs), such as obesity, diabetes, cardiovascular events and cancer, continue to rise worldwide, which require objective instruments for preventive and management actions. Diverse anthropometric and biochemical markers have been used to qualitatively evalu...

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Autores principales:	Begoña de Cuevillas, Ismael Alvarez-Alvarez, Jose I. Riezu-Boj, Santiago Navas-Carretero, J. Alfredo Martinez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74426c29eba84849a25d067085de82a9
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spelling	oai:doaj.org-article:74426c29eba84849a25d067085de82a92021-11-14T12:22:23ZThe hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits10.1038/s41598-021-01343-x2045-2322https://doaj.org/article/74426c29eba84849a25d067085de82a92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01343-xhttps://doaj.org/toc/2045-2322Abstract Rates of non-communicable diseases (NCDs), such as obesity, diabetes, cardiovascular events and cancer, continue to rise worldwide, which require objective instruments for preventive and management actions. Diverse anthropometric and biochemical markers have been used to qualitatively evaluate degrees of disease, metabolic traits and evolution of nutritional status. The aim of this study was to integrate and assess the interactions between an anthropometric measurement, such as waist circumference (WC), and biochemical data, such as the triglyceride glucose index (TyG), in order to individually characterize metabolic syndrome (MetS) features considering the hypertriglyceridemic waist phenotype as a marker. An ancillary cross-sectional study was conducted using anthropometric measurements, such as weight, height, waist and hip circumferences, as well as fasting biochemical data of 314 participants. Different indices based on WC (WC, WCTG and WCTyG) were estimated to compute MetS components and accompanying comorbidities. ROC curves were fitted to define the strength of the analyses and the validity of the relationships. Associations were confirmed between anthropometric, biochemical and combined indices with some chronic disease manifestations, including hyperglycemia, hypertension and dyslipidemia. Both WCTG and WCTyG indices showed similar performance in diagnosing MetS (area under the ROC curve = 0.81). Interestingly, when participants were categorized according to a reference value of the WCTyG index (842.7 cmmg/dl), our results evidenced that subjects classified over this limit presented statistically higher prevalence of MetS and accompanying individual components with clinical relevance for interventions. These results revealed that WC*TyG mirrors the hypertriglyceridemic phenotype, which suggests may serve as a good indicator to define the metabolic syndrome phenotype and a suitable, sensitive, and simple proxy to complement others. A reference point was proposed with a good clinical performance and maximized sensitivity and specificity values.Begoña de CuevillasIsmael Alvarez-AlvarezJose I. Riezu-BojSantiago Navas-CarreteroJ. Alfredo MartinezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Begoña de Cuevillas Ismael Alvarez-Alvarez Jose I. Riezu-Boj Santiago Navas-Carretero J. Alfredo Martinez The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
description	Abstract Rates of non-communicable diseases (NCDs), such as obesity, diabetes, cardiovascular events and cancer, continue to rise worldwide, which require objective instruments for preventive and management actions. Diverse anthropometric and biochemical markers have been used to qualitatively evaluate degrees of disease, metabolic traits and evolution of nutritional status. The aim of this study was to integrate and assess the interactions between an anthropometric measurement, such as waist circumference (WC), and biochemical data, such as the triglyceride glucose index (TyG), in order to individually characterize metabolic syndrome (MetS) features considering the hypertriglyceridemic waist phenotype as a marker. An ancillary cross-sectional study was conducted using anthropometric measurements, such as weight, height, waist and hip circumferences, as well as fasting biochemical data of 314 participants. Different indices based on WC (WC, WCTG and WCTyG) were estimated to compute MetS components and accompanying comorbidities. ROC curves were fitted to define the strength of the analyses and the validity of the relationships. Associations were confirmed between anthropometric, biochemical and combined indices with some chronic disease manifestations, including hyperglycemia, hypertension and dyslipidemia. Both WCTG and WCTyG indices showed similar performance in diagnosing MetS (area under the ROC curve = 0.81). Interestingly, when participants were categorized according to a reference value of the WCTyG index (842.7 cmmg/dl), our results evidenced that subjects classified over this limit presented statistically higher prevalence of MetS and accompanying individual components with clinical relevance for interventions. These results revealed that WC*TyG mirrors the hypertriglyceridemic phenotype, which suggests may serve as a good indicator to define the metabolic syndrome phenotype and a suitable, sensitive, and simple proxy to complement others. A reference point was proposed with a good clinical performance and maximized sensitivity and specificity values.
format	article
author	Begoña de Cuevillas Ismael Alvarez-Alvarez Jose I. Riezu-Boj Santiago Navas-Carretero J. Alfredo Martinez
author_facet	Begoña de Cuevillas Ismael Alvarez-Alvarez Jose I. Riezu-Boj Santiago Navas-Carretero J. Alfredo Martinez
author_sort	Begoña de Cuevillas
title	The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
title_short	The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
title_full	The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
title_fullStr	The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
title_full_unstemmed	The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
title_sort	hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74426c29eba84849a25d067085de82a9
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The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits

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