The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients

Background: Lead poisoning was on the rise in recent years. There exists a lack of easy access to some of the main chelator drugs in developing countries. Thus, this study aimed to explore the comparative effects of Succimer and D-Penicillamine on acute lead poisoning patients from 2013 to 2018. Me...

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Autores principales:	Gholamali, Negar Molavi, Rokhsareh Meamar, Akbar Hasanzadeh, Nastaran Eizadi-Mood
Formato:	article
Lenguaje:	EN
Publicado:	Shaheed Beheshti University of Medical Sciences 2021
Materias:	d-penicillamine succimer poisoning lead treatment Medicine (General) R5-920 Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doi.org/10.32598/ijmtfm.v11i3.33474 https://doaj.org/article/744516637ad045ab886a8e157425be1f
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spelling	oai:doaj.org-article:744516637ad045ab886a8e157425be1f2021-11-08T07:04:55ZThe Effects of Succimer and Penicillamine on Acute Lead Poisoning Patientshttps://doi.org/10.32598/ijmtfm.v11i3.334742251-87622251-8770https://doaj.org/article/744516637ad045ab886a8e157425be1f2021-08-01T00:00:00Zhttps://journals.sbmu.ac.ir/ijmtfm/article/view/33474https://doaj.org/toc/2251-8762https://doaj.org/toc/2251-8770Background: Lead poisoning was on the rise in recent years. There exists a lack of easy access to some of the main chelator drugs in developing countries. Thus, this study aimed to explore the comparative effects of Succimer and D-Penicillamine on acute lead poisoning patients from 2013 to 2018. Methods: This descriptive study was conducted in the Clinical Toxicology Department of Khorshid Hospital in Isfahan City, Iran. Adult patients with acute lead poisoning were included in the study. Patients in the 3 treatment groups of D-Penicillamine, D-Penicillamine with succimer, and succimer were compared concerning demographic characteristics as well as clinical and laboratory findings at admission time and two weeks later. Results: In total, 163 patients were evaluated in this research. There was no significant difference between the treatment groups respecting improvement in clinical symptoms. The mean blood lead levels during hospitalization and two weeks after the treatment did not significantly differ between the three groups; however, there was a significant reduction in all study groups after two weeks of treatment (P<0.05). The mean white blood cell count was significantly lower only in the D-Penicillamine group two weeks after hospitalization (P<0.05). In the D-Penicillamine group, the mean platelet, hematocrit, and hemoglobin levels were significantly lower two weeks after hospitalization, although within the healthy range. Conclusion: D-Penicillamine may be an acceptable chelator drug for treating patients with acute lead poisoning, especially in communities without access to drugs, like succimer.Gholamali Negar MolaviRokhsareh MeamarAkbar HasanzadehNastaran Eizadi-MoodShaheed Beheshti University of Medical Sciencesarticled-penicillaminesuccimerpoisoningleadtreatmentMedicine (General)R5-920Toxicology. PoisonsRA1190-1270ENInternational Journal of Medical Toxicology and Forensic Medicine, Vol 11, Iss 3, p 33474 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	d-penicillamine succimer poisoning lead treatment Medicine (General) R5-920 Toxicology. Poisons RA1190-1270
spellingShingle	d-penicillamine succimer poisoning lead treatment Medicine (General) R5-920 Toxicology. Poisons RA1190-1270 Gholamali Negar Molavi Rokhsareh Meamar Akbar Hasanzadeh Nastaran Eizadi-Mood The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients
description	Background: Lead poisoning was on the rise in recent years. There exists a lack of easy access to some of the main chelator drugs in developing countries. Thus, this study aimed to explore the comparative effects of Succimer and D-Penicillamine on acute lead poisoning patients from 2013 to 2018. Methods: This descriptive study was conducted in the Clinical Toxicology Department of Khorshid Hospital in Isfahan City, Iran. Adult patients with acute lead poisoning were included in the study. Patients in the 3 treatment groups of D-Penicillamine, D-Penicillamine with succimer, and succimer were compared concerning demographic characteristics as well as clinical and laboratory findings at admission time and two weeks later. Results: In total, 163 patients were evaluated in this research. There was no significant difference between the treatment groups respecting improvement in clinical symptoms. The mean blood lead levels during hospitalization and two weeks after the treatment did not significantly differ between the three groups; however, there was a significant reduction in all study groups after two weeks of treatment (P<0.05). The mean white blood cell count was significantly lower only in the D-Penicillamine group two weeks after hospitalization (P<0.05). In the D-Penicillamine group, the mean platelet, hematocrit, and hemoglobin levels were significantly lower two weeks after hospitalization, although within the healthy range. Conclusion: D-Penicillamine may be an acceptable chelator drug for treating patients with acute lead poisoning, especially in communities without access to drugs, like succimer.
format	article
author	Gholamali Negar Molavi Rokhsareh Meamar Akbar Hasanzadeh Nastaran Eizadi-Mood
author_facet	Gholamali Negar Molavi Rokhsareh Meamar Akbar Hasanzadeh Nastaran Eizadi-Mood
author_sort	Gholamali
title	The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients
title_short	The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients
title_full	The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients
title_fullStr	The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients
title_full_unstemmed	The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients
title_sort	effects of succimer and penicillamine on acute lead poisoning patients
publisher	Shaheed Beheshti University of Medical Sciences
publishDate	2021
url	https://doi.org/10.32598/ijmtfm.v11i3.33474 https://doaj.org/article/744516637ad045ab886a8e157425be1f
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The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients

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